Detailed information of TA system TA222414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1813248..1813868
• Replicon: chromosome
• Accession: NZ_CP085987
• Organism: Salmonella enterica strain SZL 38

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LKX03_RS09660
• Protein ID: WP_001280991.1
• Coordinates: 1813650..1813868 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LKX03_RS09655
• Protein ID: WP_000344807.1
• Coordinates: 1813248..1813622 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LKX03_RS09645 (1808387)	1808387..1809580	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LKX03_RS09650 (1809603)	1809603..1812752	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LKX03_RS09655 (1813248)	1813248..1813622	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LKX03_RS09660 (1813650)	1813650..1813868	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LKX03_RS09665 (1814047)	1814047..1814598	+	552	WP_001278792.1	maltose O-acetyltransferase	-
LKX03_RS09670 (1814715)	1814715..1815185	+	471	WP_000136181.1	YlaC family protein	-
LKX03_RS09675 (1815241)	1815241..1815381	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LKX03_RS09680 (1815387)	1815387..1815647	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LKX03_RS09685 (1815872)	1815872..1817422	+	1551	WP_000213139.1	EAL domain-containing protein	-
LKX03_RS09695 (1817653)	1817653..1818042	+	390	WP_000961285.1	MGMT family protein	-
LKX03_RS09700 (1818075)	1818075..1818644	-	570	WP_000779803.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T222414 WP_001280991.1 NZ_CP085987:1813650-1813868 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T222414 NZ_CP117851:c1347474-1346983 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT222414 WP_000344807.1 NZ_CP085987:1813248-1813622 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT222414 NZ_CP117851:c1347764-1347471 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0