222404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 8211..8733 Replicon plasmid pSZL31.2
Accession NZ_CP085985
Organism Salmonella enterica strain SZL 31

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag LJY15_RS24145 Protein ID WP_000220560.1
Coordinates 8452..8733 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag LJY15_RS24140 Protein ID WP_000121743.1
Coordinates 8211..8462 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY15_RS24110 (LJY15_24110) 3289..3951 + 663 WP_050871575.1 division plane positioning ATPase MipZ -
LJY15_RS24115 (LJY15_24115) 4051..4332 + 282 WP_001185482.1 hypothetical protein -
LJY15_RS24120 (LJY15_24120) 4357..5334 + 978 WP_001579336.1 hypothetical protein -
LJY15_RS24125 (LJY15_24125) 5331..5687 - 357 WP_001576907.1 DNA distortion polypeptide 3 -
LJY15_RS24130 (LJY15_24130) 5824..6270 - 447 WP_001074386.1 hypothetical protein -
LJY15_RS24135 (LJY15_24135) 6295..7149 - 855 WP_001239324.1 replication initiation protein -
LJY15_RS24140 (LJY15_24140) 8211..8462 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
LJY15_RS24145 (LJY15_24145) 8452..8733 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJY15_RS24150 (LJY15_24150) 8879..9202 + 324 WP_001181903.1 hypothetical protein -
LJY15_RS24155 (LJY15_24155) 9247..9492 + 246 WP_000356546.1 hypothetical protein -
LJY15_RS24160 (LJY15_24160) 9482..9697 + 216 WP_001180116.1 hypothetical protein -
LJY15_RS24165 (LJY15_24165) 9790..10119 + 330 WP_000866648.1 hypothetical protein -
LJY15_RS24170 (LJY15_24170) 10162..10341 + 180 WP_000439078.1 hypothetical protein -
LJY15_RS24175 (LJY15_24175) 10411..10560 + 150 WP_000003880.1 hypothetical protein -
LJY15_RS24180 (LJY15_24180) 10573..10845 + 273 WP_000160399.1 hypothetical protein -
LJY15_RS24185 (LJY15_24185) 11171..11716 + 546 WP_000757693.1 DNA distortion polypeptide 1 -
LJY15_RS24190 (LJY15_24190) 11719..12885 + 1167 WP_001576909.1 MobP1 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / sul3 / cmlA1 - 1..53154 53154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T222404 WP_000220560.1 NZ_CP085985:8452-8733 [Salmonella enterica]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T222404 NZ_CP117850:4577308-4577553 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATCAACAGCAAAGCCTGCATGACCACCTGTTACTCACAAATCCCCAGCCAGCACCTTAAGGGTGACTGGCAGGAAGAAGC
GGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTTTGATCCTGATTGCAGAGACGGACGAAGTGA
GGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACGGG
GATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT222404 WP_000121743.1 NZ_CP085985:8211-8462 [Salmonella enterica]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT222404 NZ_CP117850:c4577543-4577132 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References