Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 73676..74201 | Replicon | plasmid pSZL31.1 |
| Accession | NZ_CP085984 | ||
| Organism | Salmonella enterica strain SZL 31 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A5Y5FBU7 |
| Locus tag | LJY15_RS23115 | Protein ID | WP_023994134.1 |
| Coordinates | 73896..74201 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A5T8X4Y4 |
| Locus tag | LJY15_RS23110 | Protein ID | WP_023994135.1 |
| Coordinates | 73676..73894 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJY15_RS23075 (LJY15_23075) | 68708..69472 | + | 765 | WP_023994141.1 | minor fimbrial protein | - |
| LJY15_RS23080 (LJY15_23080) | 69675..70265 | + | 591 | WP_023994140.1 | hypothetical protein | - |
| LJY15_RS23085 (LJY15_23085) | 70367..70543 | + | 177 | WP_230374870.1 | FaeA/PapI family transcriptional regulator | - |
| LJY15_RS23090 (LJY15_23090) | 70804..70965 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| LJY15_RS23095 (LJY15_23095) | 70991..71839 | + | 849 | WP_023994138.1 | SdiA-regulated domain-containing protein | - |
| LJY15_RS23100 (LJY15_23100) | 72409..72825 | - | 417 | WP_023994137.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJY15_RS23105 (LJY15_23105) | 72822..73052 | - | 231 | WP_023994136.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LJY15_RS23110 (LJY15_23110) | 73676..73894 | + | 219 | WP_023994135.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| LJY15_RS23115 (LJY15_23115) | 73896..74201 | + | 306 | WP_023994134.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| LJY15_RS23120 (LJY15_23120) | 74203..74493 | + | 291 | WP_023994133.1 | hypothetical protein | - |
| LJY15_RS24485 | 74490..74558 | + | 69 | Protein_86 | hypothetical protein | - |
| LJY15_RS24490 | 74568..74717 | + | 150 | Protein_87 | 3'-5' exonuclease | - |
| LJY15_RS23130 (LJY15_23130) | 74836..74952 | + | 117 | Protein_88 | hypothetical protein | - |
| LJY15_RS23135 (LJY15_23135) | 74942..75657 | - | 716 | Protein_89 | transposase | - |
| LJY15_RS23140 (LJY15_23140) | 76939..77475 | + | 537 | WP_023994130.1 | fimbrial protein | - |
| LJY15_RS23145 (LJY15_23145) | 77528..78259 | + | 732 | WP_023994129.1 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aadA2 / dfrA14 / cmlA1 / sul3 / tet(A) | faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..280239 | 280239 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11708.47 Da Isoelectric Point: 6.4685
>T222403 WP_023994134.1 NZ_CP085984:73896-74201 [Salmonella enterica]
MQFKVYTYKRESRYRLFVDVQSDIVDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASFIGEEV
AELSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYRLFVDVQSDIVDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASFIGEEV
AELSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T222403 NZ_CP117850:4573551-4573796 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8261.18 Da Isoelectric Point: 4.7405
>AT222403 WP_023994135.1 NZ_CP085984:73676-73894 [Salmonella enterica]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQKEARRLRAERWQAENQEGMAEVARFIEANGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQKEARRLRAERWQAENQEGMAEVARFIEANGSFADENRDW
Download Length: 219 bp
>AT222403 NZ_CP117850:c4573701-4573394 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y5FBU7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T8X4Y4 |