Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/DUF1778(antitoxin) |
| Location | 52390..53147 | Replicon | plasmid pSZL31.1 |
| Accession | NZ_CP085984 | ||
| Organism | Salmonella enterica strain SZL 31 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A241PXX4 |
| Locus tag | LJY15_RS22975 | Protein ID | WP_023994162.1 |
| Coordinates | 52665..53147 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A727Z1I8 |
| Locus tag | LJY15_RS22970 | Protein ID | WP_001195098.1 |
| Coordinates | 52390..52674 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJY15_RS22925 (LJY15_22925) | 48231..48377 | - | 147 | Protein_47 | IS66 family insertion sequence element accessory protein TnpB | - |
| LJY15_RS22930 (LJY15_22930) | 48364..48693 | - | 330 | WP_023994169.1 | hypothetical protein | - |
| LJY15_RS22935 (LJY15_22935) | 48817..49670 | + | 854 | Protein_49 | site-specific tyrosine recombinase XerC | - |
| LJY15_RS22940 (LJY15_22940) | 49639..49926 | + | 288 | WP_031619580.1 | damage-inducible protein J | - |
| LJY15_RS22945 (LJY15_22945) | 49923..50228 | + | 306 | WP_023994167.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LJY15_RS22950 (LJY15_22950) | 50978..51241 | + | 264 | WP_023994165.1 | DUF977 family protein | - |
| LJY15_RS22955 (LJY15_22955) | 51267..51602 | + | 336 | WP_023994164.1 | hypothetical protein | - |
| LJY15_RS22960 (LJY15_22960) | 51824..52021 | - | 198 | Protein_54 | PIN domain-containing protein | - |
| LJY15_RS22965 (LJY15_22965) | 52145..52234 | + | 90 | WP_071790431.1 | helix-turn-helix domain-containing protein | - |
| LJY15_RS22970 (LJY15_22970) | 52390..52674 | + | 285 | WP_001195098.1 | DUF1778 domain-containing protein | Antitoxin |
| LJY15_RS22975 (LJY15_22975) | 52665..53147 | + | 483 | WP_023994162.1 | GNAT family N-acetyltransferase | Toxin |
| LJY15_RS22980 (LJY15_22980) | 53462..53888 | + | 427 | Protein_58 | transposase | - |
| LJY15_RS22985 (LJY15_22985) | 54205..54414 | + | 210 | WP_023994160.1 | hemolysin expression modulator Hha | - |
| LJY15_RS22990 (LJY15_22990) | 54488..54840 | - | 353 | Protein_60 | transposase | - |
| LJY15_RS22995 (LJY15_22995) | 55067..56040 | + | 974 | Protein_61 | IS256 family transposase | - |
| LJY15_RS23000 (LJY15_23000) | 56042..56284 | + | 243 | WP_023994156.1 | hypothetical protein | - |
| LJY15_RS23005 (LJY15_23005) | 56355..57311 | + | 957 | WP_023994155.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| LJY15_RS23010 (LJY15_23010) | 57370..57582 | + | 213 | WP_023994154.1 | hypothetical protein | - |
| LJY15_RS23015 (LJY15_23015) | 57624..57875 | - | 252 | WP_023994153.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aadA2 / dfrA14 / cmlA1 / sul3 / tet(A) | faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..280239 | 280239 | |
| - | inside | IScluster/Tn | - | - | 46935..59439 | 12504 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17971.54 Da Isoelectric Point: 6.8521
>T222401 WP_023994162.1 NZ_CP085984:52665-53147 [Salmonella enterica]
MEISVTAPELLNEEHYLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPEGTKRVVGYYSIATGSVSHASLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPIAPNTLFYKI
MEISVTAPELLNEEHYLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPEGTKRVVGYYSIATGSVSHASLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPIAPNTLFYKI
Download Length: 483 bp
>T222401 NZ_CP117850:3350379-3350663 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10964.52 Da Isoelectric Point: 9.6539
>AT222401 WP_001195098.1 NZ_CP085984:52390-52674 [Salmonella enterica]
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK
Download Length: 285 bp
>AT222401 NZ_CP117850:3350141-3350389 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A241PXX4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A727Z1I8 |