Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 38310..38900 Replicon plasmid pSZL31.1
Accession NZ_CP085984
Organism Salmonella enterica strain SZL 31

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag LJY15_RS22890 Protein ID WP_023994178.1
Coordinates 38568..38900 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag LJY15_RS22885 Protein ID WP_023994179.1
Coordinates 38310..38567 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY15_RS22865 (LJY15_22865) 33809..34834 + 1026 WP_227945772.1 IS630 family transposase -
LJY15_RS22870 (LJY15_22870) 34838..35857 - 1020 WP_223155817.1 hypothetical protein -
LJY15_RS22875 (LJY15_22875) 35997..36503 - 507 WP_223155815.1 hypothetical protein -
LJY15_RS22880 (LJY15_22880) 36614..37699 - 1086 WP_223155813.1 hypothetical protein -
LJY15_RS22885 (LJY15_22885) 38310..38567 + 258 WP_023994179.1 hypothetical protein Antitoxin
LJY15_RS22890 (LJY15_22890) 38568..38900 + 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LJY15_RS22895 (LJY15_22895) 39500..40105 + 606 Protein_41 IS481 family transposase -
LJY15_RS22900 (LJY15_22900) 40404..42626 - 2223 WP_023994175.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aadA2 / dfrA14 / cmlA1 / sul3 / tet(A) faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..280239 280239
- inside IScluster/Tn - - 33797..40105 6308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11787.54 Da        Isoelectric Point: 9.3417

>T222400 WP_023994178.1 NZ_CP085984:38568-38900 [Salmonella enterica]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

>T222400 NZ_CP117850:c3011565-3011254 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAGAGATTTCTCTTCTCCGGCAGAGCTACGAAAAGTCATACCGAGTCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTACTACAGGGAGAATAAAGAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9374.86 Da        Isoelectric Point: 4.4354

>AT222400 WP_023994179.1 NZ_CP085984:38310-38567 [Salmonella enterica]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL

Download         Length: 258 bp

>AT222400 NZ_CP117850:c3011257-3010838 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTAGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGTGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAAATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References