Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2943387..2944101 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag TBFG_RS13820 Protein ID WP_003413460.1
Coordinates 2943661..2944101 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag TBFG_RS13815 Protein ID WP_003413456.1
Coordinates 2943387..2943674 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS13780 2938809..2939054 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
TBFG_RS13785 2939051..2939455 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
TBFG_RS13790 2939672..2940292 + 621 WP_003413441.1 DUF4178 domain-containing protein -
TBFG_RS13795 2940303..2940797 + 495 WP_003413444.1 DUF2617 family protein -
TBFG_RS13800 2940794..2941225 + 432 WP_003899390.1 DUF4247 domain-containing protein -
TBFG_RS13805 2941250..2941708 + 459 WP_003413451.1 DUF350 domain-containing protein -
TBFG_RS13810 2941705..2943276 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
TBFG_RS13815 2943387..2943674 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
TBFG_RS13820 2943661..2944101 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
TBFG_RS13825 2944122..2944877 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
TBFG_RS13830 2945010..2945606 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
TBFG_RS13835 2945614..2946459 - 846 WP_003413466.1 acyl-CoA thioesterase II -
TBFG_RS13840 2946488..2947387 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
TBFG_RS13845 2947515..2948189 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T22240 WP_003413460.1 NC_009565:2943661-2944101 [Mycobacterium tuberculosis F11]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T22240 NC_009565:2943661-2944101 [Mycobacterium tuberculosis F11]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT22240 WP_003413456.1 NC_009565:2943387-2943674 [Mycobacterium tuberculosis F11]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT22240 NC_009565:2943387-2943674 [Mycobacterium tuberculosis F11]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References