Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 4262383..4262899 Replicon chromosome
Accession NZ_CP085983
Organism Salmonella enterica strain SZL 31

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag LJY15_RS20685 Protein ID WP_023993574.1
Coordinates 4262383..4262667 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag LJY15_RS20690 Protein ID WP_023993575.1
Coordinates 4262657..4262899 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY15_RS20670 (4257499) 4257499..4259151 + 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -
LJY15_RS20675 (4259560) 4259560..4261698 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJY15_RS20680 (4261915) 4261915..4262379 + 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJY15_RS20685 (4262383) 4262383..4262667 - 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJY15_RS20690 (4262657) 4262657..4262899 - 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJY15_RS20695 (4262977) 4262977..4264890 - 1914 WP_023993576.1 BglG family transcription antiterminator -
LJY15_RS20700 (4264907) 4264907..4265647 - 741 WP_023993577.1 KDGP aldolase family protein -
LJY15_RS20705 (4265644) 4265644..4266762 - 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJY15_RS20710 (4266746) 4266746..4267879 - 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T222399 WP_023993574.1 NZ_CP085983:c4262667-4262383 [Salmonella enterica]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T222399 NZ_CP117850:3004256-3004359 [Salmonella enterica subsp. enterica serovar Mbandaka]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT222399 WP_023993575.1 NZ_CP085983:c4262899-4262657 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp

>AT222399 NZ_CP117850:c3004361-3004218 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAAGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References