Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3593615..3594235 Replicon chromosome
Accession NZ_CP085983
Organism Salmonella enterica strain SZL 31

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJY15_RS17565 Protein ID WP_001280991.1
Coordinates 3594017..3594235 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJY15_RS17560 Protein ID WP_000344807.1
Coordinates 3593615..3593989 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY15_RS17550 (3588754) 3588754..3589947 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJY15_RS17555 (3589970) 3589970..3593119 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJY15_RS17560 (3593615) 3593615..3593989 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJY15_RS17565 (3594017) 3594017..3594235 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJY15_RS17570 (3594414) 3594414..3594965 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJY15_RS17575 (3595083) 3595083..3595553 + 471 WP_000136183.1 YlaC family protein -
LJY15_RS17580 (3595609) 3595609..3595749 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJY15_RS17585 (3595755) 3595755..3596015 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJY15_RS17590 (3596240) 3596240..3597790 + 1551 WP_000213140.1 EAL domain-containing protein -
LJY15_RS17600 (3598021) 3598021..3598410 + 390 WP_000961285.1 MGMT family protein -
LJY15_RS17605 (3598443) 3598443..3599012 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T222395 WP_001280991.1 NZ_CP085983:3594017-3594235 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T222395 NZ_CP117850:1317672-1318040 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT222395 WP_000344807.1 NZ_CP085983:3593615-3593989 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT222395 NZ_CP117850:1317454-1317675 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References