Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2883045..2883682 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag TBFG_RS13550 Protein ID WP_003413180.1
Coordinates 2883045..2883440 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag TBFG_RS13555 Protein ID WP_003413183.1
Coordinates 2883437..2883682 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS13510 2878448..2879659 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
TBFG_RS13515 2879786..2880445 + 660 WP_003900846.1 LppA family lipoprotein -
TBFG_RS13520 2880442..2881104 + 663 WP_003900848.1 hypothetical protein -
TBFG_RS13525 2881101..2881379 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
TBFG_RS13530 2881472..2881885 + 414 WP_003413164.1 PIN domain nuclease -
TBFG_RS13535 2881924..2882181 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
TBFG_RS13540 2882178..2882555 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
TBFG_RS13545 2882571..2882945 - 375 WP_003413177.1 hypothetical protein -
TBFG_RS13550 2883045..2883440 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
TBFG_RS13555 2883437..2883682 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
TBFG_RS13560 2884093..2884512 - 420 WP_003413190.1 A24 family peptidase -
TBFG_RS13565 2884524..2885333 - 810 WP_003413193.1 shikimate dehydrogenase -
TBFG_RS13570 2885330..2886583 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
TBFG_RS13575 2886576..2887088 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T22239 WP_003413180.1 NC_009565:c2883440-2883045 [Mycobacterium tuberculosis F11]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T22239 NC_009565:c2883440-2883045 [Mycobacterium tuberculosis F11]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT22239 WP_003413183.1 NC_009565:c2883682-2883437 [Mycobacterium tuberculosis F11]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT22239 NC_009565:c2883682-2883437 [Mycobacterium tuberculosis F11]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References