Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1089559..1090219 Replicon chromosome
Accession NZ_CP085983
Organism Salmonella enterica strain SZL 31

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag LJY15_RS05295 Protein ID WP_000244761.1
Coordinates 1089806..1090219 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJY15_RS05290 Protein ID WP_000351186.1
Coordinates 1089559..1089825 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY15_RS05270 (1085488) 1085488..1086921 - 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -
LJY15_RS05275 (1087079) 1087079..1087390 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJY15_RS05280 (1087554) 1087554..1088213 + 660 WP_000250289.1 hemolysin III family protein -
LJY15_RS05285 (1088329) 1088329..1089309 - 981 WP_023260866.1 tRNA-modifying protein YgfZ -
LJY15_RS05290 (1089559) 1089559..1089825 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJY15_RS05295 (1089806) 1089806..1090219 + 414 WP_000244761.1 protein YgfX Toxin
LJY15_RS05300 (1090272) 1090272..1090793 - 522 WP_001055885.1 flavodoxin FldB -
LJY15_RS05305 (1090906) 1090906..1091802 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJY15_RS05310 (1091826) 1091826..1092539 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJY15_RS05315 (1092545) 1092545..1094278 + 1734 WP_149385273.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T222384 WP_000244761.1 NZ_CP085983:1089806-1090219 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T222384 NZ_CP117838:c2832947-2832844 [Enterobacter sp. S-33]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT222384 WP_000351186.1 NZ_CP085983:1089559-1089825 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT222384 NZ_CP117838:2832839-2832982 [Enterobacter sp. S-33]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References