222382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 447367..448127 Replicon chromosome
Accession NZ_CP085983
Organism Salmonella enterica strain SZL 31

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LJY15_RS02190 Protein ID WP_000533909.1
Coordinates 447642..448127 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJY15_RS02185 Protein ID WP_000965886.1
Coordinates 447367..447654 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY15_RS02165 (444070) 444070..444498 + 429 Protein_417 IS3 family transposase -
LJY15_RS02170 (444617) 444617..445267 - 651 WP_023993641.1 GntR family transcriptional regulator -
LJY15_RS02175 (445352) 445352..446554 + 1203 WP_023201740.1 MFS transporter -
LJY15_RS02180 (446643) 446643..447201 + 559 Protein_420 cysteine hydrolase -
LJY15_RS02185 (447367) 447367..447654 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJY15_RS02190 (447642) 447642..448127 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LJY15_RS02195 (448499) 448499..449038 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
LJY15_RS02200 (449212) 449212..449424 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJY15_RS02205 (449712) 449712..450002 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJY15_RS02210 (450441) 450441..451151 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJY15_RS02215 (451201) 451201..452175 - 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJY15_RS02220 (452394) 452394..453056 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T222382 WP_000533909.1 NZ_CP085983:447642-448127 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T222382 NZ_CP117838:c1170110-1169799 [Enterobacter sp. S-33]
ATGCACGTAGTCTCAAGAGCGCCTTTCGATACGGCGACCAGACATTTTCCCAATCAAGCACTCGCCCTGGACGATCTTTA
CCGGGTACTAAAGAAGGAACACTACTCGTCACCAGGCGACATGCGAAAGCGCTTTCCCACCCTGGACCGGATGAAATACC
GGGAAAAATGGTGGGTCATTGATGTAGGTGGCGGACATTTAAGAGTAATATTTTTTGCTGATTTTGAGCGGGGAAAGATC
TTCATTAAACACATCAGCACGCACGCAGAGTATGACAAGCTCACGGACCTCTACCGGAGAACGAAAGAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT222382 WP_000965886.1 NZ_CP085983:447367-447654 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT222382 NZ_CP117838:c1169802-1169383 [Enterobacter sp. S-33]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGAGCTGACTAACGAGCTTCCCTTCCTGGGCTCAAGCCCGTCGCGACA
AGATTACGAGGATGCTCTGGCGATGGTGGAACATCTTATTGAGCACGAACCCGATAGCCCGCTGGTAGAGATGCTTACCG
CGAAAATCGATAAATACGAAAACGAGTCTCCGGAGTTTGCAGAATTTAACGCGCGTGTTGCCCGCATTCCGTCAGGCGTT
GCGTTATTACGAACATTGATGGATCAGTACCAACTCACTCAGAGCGATTTCGAGAACGAGATTGGCAAAAAGTCTCTGGT
AAGTCGGATCCTTAATGGACAGCGCACATTGACCCTGGATCATATGCGTGCGCTGGCGAAGCGTTTCGGTTTGCCTGTGA
GTGCGTTTGTGGGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References