Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 29327..30084 Replicon plasmid pSZL30.1
Accession NZ_CP085982
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name tacT Uniprot ID A0A241PXX4
Locus tag LJY16_RS23200 Protein ID WP_023994162.1
Coordinates 29327..29809 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A727Z1I8
Locus tag LJY16_RS23205 Protein ID WP_001195098.1
Coordinates 29800..30084 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS23160 (LJY16_23160) 24599..24850 + 252 WP_023994153.1 helix-turn-helix domain-containing protein -
LJY16_RS23165 (LJY16_23165) 24892..25104 - 213 WP_023994154.1 hypothetical protein -
LJY16_RS23170 (LJY16_23170) 25163..26119 - 957 WP_023994155.1 Rpn family recombination-promoting nuclease/putative transposase -
LJY16_RS23175 (LJY16_23175) 26190..26432 - 243 WP_023994156.1 hypothetical protein -
LJY16_RS24400 26419..26661 - 243 WP_023994157.1 IS256 family transposase -
LJY16_RS24405 26661..27173 - 513 Protein_33 transposase -
LJY16_RS23185 (LJY16_23185) 27634..27986 + 353 Protein_34 transposase -
LJY16_RS23190 (LJY16_23190) 28060..28269 - 210 WP_023994160.1 hemolysin expression modulator Hha -
LJY16_RS23195 (LJY16_23195) 28586..29012 - 427 Protein_36 transposase -
LJY16_RS23200 (LJY16_23200) 29327..29809 - 483 WP_023994162.1 GNAT family N-acetyltransferase Toxin
LJY16_RS23205 (LJY16_23205) 29800..30084 - 285 WP_001195098.1 DUF1778 domain-containing protein Antitoxin
LJY16_RS23210 (LJY16_23210) 30240..30329 - 90 WP_071790431.1 helix-turn-helix domain-containing protein -
LJY16_RS23215 (LJY16_23215) 30453..30650 + 198 Protein_40 PIN domain-containing protein -
LJY16_RS23220 (LJY16_23220) 30872..31207 - 336 WP_023994164.1 hypothetical protein -
LJY16_RS23225 (LJY16_23225) 31233..31496 - 264 WP_023994165.1 DUF977 family protein -
LJY16_RS23230 (LJY16_23230) 32246..32551 - 306 WP_023994167.1 type II toxin-antitoxin system RelE/ParE family toxin -
LJY16_RS23235 (LJY16_23235) 32548..32835 - 288 WP_031619580.1 damage-inducible protein J -
LJY16_RS23240 (LJY16_23240) 32804..33657 - 854 Protein_45 site-specific tyrosine recombinase XerC -
LJY16_RS23245 (LJY16_23245) 33781..34110 + 330 WP_023994169.1 hypothetical protein -
LJY16_RS23250 (LJY16_23250) 34097..34243 + 147 Protein_47 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA14 / tet(A) faeI / faeH / faeF / faeE / faeD / faeC / ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..272840 272840
- inside IScluster/Tn - - 23035..35539 12504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-149)

Antitoxin

Vibrio phage ICP1, Orf50

(13-88)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17971.54 Da        Isoelectric Point: 6.8521

>T222378 WP_023994162.1 NZ_CP085982:c29809-29327 [Salmonella enterica]
MEISVTAPELLNEEHYLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPEGTKRVVGYYSIATGSVSHASLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPIAPNTLFYKI

Download         Length: 483 bp

>T222378 NZ_CP117834:c690871-690521 [Shouchella hunanensis]
TTGATAGTGAAACGGGGAGATGTCTATTTTGCTGATCTATCTCCAGTTGTAGGATCAGAACAAGGTGGGGTACGACCAGT
TCTCATCATTCAAAATAACATTGGAAATCGATTTAGTCCTACGGTAATTGTTGCAGCGATAACGGCACAAATCCAAAAAG
CTAAATTACCTACGCATGTTGAAATTAATGCAAGCAAGTACGGATTTGATCGAGATTCTGTTATTTTACTTGAACAGCTT
CGAACAATTGATAAACAAAGATTAACAGATAAAATTACTCATCTAGATGAAAAGATGATGCAGTCGGTAGACAAGGCATT
GACTATTAGTTTAGGTTTAATTGATTTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10964.52 Da        Isoelectric Point: 9.6539

>AT222378 WP_001195098.1 NZ_CP085982:c30084-29800 [Salmonella enterica]
MQTTIRKSVRNKQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK

Download         Length: 285 bp

>AT222378 NZ_CP117834:c691081-690875 [Shouchella hunanensis]
TTGAATGAGGTGGACATTGTGCTTGAACAAGAAAAATGGAATGATCCAAGATTAAAAGACCGTGCTGAACTAAAGGCTGA
AATTCGCGAATCGATGCAACAAGGCTATATGGAAATGGCAAAGATTAATCTAACCATTGCATCAGAAGCTTTTCTTGCTG
AGGAGGAAGCTAATCATACGCTGACACGTCTCGTTAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXX4

Antitoxin

Source ID Structure
AlphaFold DB A0A727Z1I8

References