Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 9422..10065 | Replicon | plasmid pSZL30.1 |
| Accession | NZ_CP085982 | ||
| Organism | Salmonella enterica strain SZL 30 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A5T8FJ24 |
| Locus tag | LJY16_RS23075 | Protein ID | WP_023994137.1 |
| Coordinates | 9649..10065 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A5T3Q059 |
| Locus tag | LJY16_RS23070 | Protein ID | WP_023994136.1 |
| Coordinates | 9422..9652 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJY16_RS23035 (LJY16_23035) | 4999..5535 | - | 537 | WP_023994130.1 | fimbrial protein | - |
| LJY16_RS23040 (LJY16_23040) | 6817..7532 | + | 716 | Protein_4 | transposase | - |
| LJY16_RS23045 (LJY16_23045) | 7522..7638 | - | 117 | Protein_5 | hypothetical protein | - |
| LJY16_RS23050 (LJY16_23050) | 7709..7984 | - | 276 | Protein_6 | 3'-5' exonuclease | - |
| LJY16_RS23055 (LJY16_23055) | 7981..8271 | - | 291 | WP_023994133.1 | hypothetical protein | - |
| LJY16_RS23060 (LJY16_23060) | 8273..8578 | - | 306 | WP_023994134.1 | type II toxin-antitoxin system toxin CcdB | - |
| LJY16_RS23065 (LJY16_23065) | 8580..8798 | - | 219 | WP_023994135.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| LJY16_RS23070 (LJY16_23070) | 9422..9652 | + | 231 | WP_023994136.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LJY16_RS23075 (LJY16_23075) | 9649..10065 | + | 417 | WP_023994137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LJY16_RS23080 (LJY16_23080) | 10635..11483 | - | 849 | WP_023994138.1 | SdiA-regulated domain-containing protein | - |
| LJY16_RS23085 (LJY16_23085) | 11509..11670 | - | 162 | WP_001816720.1 | hypothetical protein | - |
| LJY16_RS23090 (LJY16_23090) | 11931..12143 | - | 213 | WP_023994139.1 | FaeA/PapI family transcriptional regulator | - |
| LJY16_RS23095 (LJY16_23095) | 12209..12799 | - | 591 | WP_023994140.1 | hypothetical protein | - |
| LJY16_RS23100 (LJY16_23100) | 13002..13766 | - | 765 | WP_023994141.1 | minor fimbrial protein | - |
| LJY16_RS23105 (LJY16_23105) | 13794..14585 | - | 792 | WP_023994142.1 | F4 (K88) fimbria minor subunit FaeH | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | dfrA14 / tet(A) | faeI / faeH / faeF / faeE / faeD / faeC / ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA | 1..272840 | 272840 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15123.58 Da Isoelectric Point: 8.5291
>T222377 WP_023994137.1 NZ_CP085982:9649-10065 [Salmonella enterica]
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR
Download Length: 417 bp
>T222377 NZ_CP117825:c2322206-2321949 [Fusobacterium nucleatum]
ATGTTATTAACTTGGACCGATTTTGCATGGAAACAATATGAAGAGTTACAAGAAAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAGGGAATAGGGAAACCAGAGCCTTTACAACATGAACTTAGTG
GTTATTGGAGCAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAGTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA
ATGTTATTAACTTGGACCGATTTTGCATGGAAACAATATGAAGAGTTACAAGAAAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAGGGAATAGGGAAACCAGAGCCTTTACAACATGAACTTAGTG
GTTATTGGAGCAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAGTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8650.75 Da Isoelectric Point: 4.5881
>AT222377 WP_023994136.1 NZ_CP085982:9422-9652 [Salmonella enterica]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPGFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPGFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT222377 NZ_CP117825:c2322463-2322206 [Fusobacterium nucleatum]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAGGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAGGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T8FJ24 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T3Q059 |