222375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4611102..4611722 Replicon chromosome
Accession NZ_CP085981
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJY16_RS22655 Protein ID WP_001280991.1
Coordinates 4611102..4611320 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJY16_RS22660 Protein ID WP_000344807.1
Coordinates 4611348..4611722 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS22615 (4606325) 4606325..4606894 + 570 WP_000779802.1 YbaY family lipoprotein -
LJY16_RS22620 (4606927) 4606927..4607316 - 390 WP_000961285.1 MGMT family protein -
LJY16_RS22630 (4607547) 4607547..4609097 - 1551 WP_000213140.1 EAL domain-containing protein -
LJY16_RS22635 (4609322) 4609322..4609582 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJY16_RS22640 (4609588) 4609588..4609728 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJY16_RS22645 (4609784) 4609784..4610254 - 471 WP_000136183.1 YlaC family protein -
LJY16_RS22650 (4610372) 4610372..4610923 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJY16_RS22655 (4611102) 4611102..4611320 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJY16_RS22660 (4611348) 4611348..4611722 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJY16_RS22665 (4612218) 4612218..4615367 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJY16_RS22670 (4615390) 4615390..4616583 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T222375 WP_001280991.1 NZ_CP085981:c4611320-4611102 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T222375 NZ_CP117825:89678-89938 [Fusobacterium nucleatum]
ATGACTAATTTAGTATGGACACATAAGGCTTGGCAAGATTACCTATATTGGCAAACTCAGGATAAAAAAACTTTAAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGCTTTAAATGGGATAGGCAAACCAGAAGTATTAAAAAATGAAA
GTGCATATAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGATGGTTTTATTTGGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT222375 WP_000344807.1 NZ_CP085981:c4611722-4611348 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT222375 NZ_CP117825:89431-89685 [Fusobacterium nucleatum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTAGACAATGATGAAGATAT
TATTATAACAAGAAAAAATGAAAGAAATGTTGTTCTATTAAGTCTTGATAAATATAATGAGTTTTTAAAAGCTATGAGAA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAGGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References