Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DinJ
Location 3942442..3942958 Replicon chromosome
Accession NZ_CP085981
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name relE Uniprot ID A0A623NIH5
Locus tag LJY16_RS19535 Protein ID WP_023993574.1
Coordinates 3942674..3942958 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A633LVJ8
Locus tag LJY16_RS19530 Protein ID WP_023993575.1
Coordinates 3942442..3942684 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS19510 (3937462) 3937462..3938595 + 1134 WP_023993579.1 amidohydrolase/deacetylase family metallohydrolase -
LJY16_RS19515 (3938579) 3938579..3939697 + 1119 WP_023993578.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJY16_RS19520 (3939694) 3939694..3940434 + 741 WP_023993577.1 KDGP aldolase family protein -
LJY16_RS19525 (3940451) 3940451..3942364 + 1914 WP_023993576.1 BglG family transcription antiterminator -
LJY16_RS19530 (3942442) 3942442..3942684 + 243 WP_023993575.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJY16_RS19535 (3942674) 3942674..3942958 + 285 WP_023993574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJY16_RS19540 (3942962) 3942962..3943426 - 465 WP_023993573.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJY16_RS19545 (3943643) 3943643..3945781 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJY16_RS19550 (3946190) 3946190..3947842 - 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10925.70 Da        Isoelectric Point: 9.8739

>T222371 WP_023993574.1 NZ_CP085981:3942674-3942958 [Salmonella enterica]
MNYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T222371 NZ_CP117823:c2529062-2528754 [Xylella fastidiosa]
GTGACCATAACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8989.40 Da        Isoelectric Point: 5.0807

>AT222371 WP_023993575.1 NZ_CP085981:3942442-3942684 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTLTLSDSEDALIQTVRERLSSPQKGIKVSLDEL

Download         Length: 243 bp

>AT222371 NZ_CP117823:c2529365-2529066 [Xylella fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623NIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A633LVJ8

References