Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2881472..2882181 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag TBFG_RS13530 Protein ID WP_003413164.1
Coordinates 2881472..2881885 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag TBFG_RS13535 Protein ID WP_003413167.1
Coordinates 2881924..2882181 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS13500 2876525..2877730 - 1206 WP_003413027.1 chorismate synthase -
TBFG_RS13505 2877838..2878152 + 315 WP_009937839.1 hypothetical protein -
TBFG_RS13510 2878448..2879659 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
TBFG_RS13515 2879786..2880445 + 660 WP_003900846.1 LppA family lipoprotein -
TBFG_RS13520 2880442..2881104 + 663 WP_003900848.1 hypothetical protein -
TBFG_RS13525 2881101..2881379 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
TBFG_RS13530 2881472..2881885 + 414 WP_003413164.1 PIN domain nuclease Toxin
TBFG_RS13535 2881924..2882181 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
TBFG_RS13540 2882178..2882555 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
TBFG_RS13545 2882571..2882945 - 375 WP_003413177.1 hypothetical protein -
TBFG_RS13550 2883045..2883440 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
TBFG_RS13555 2883437..2883682 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
TBFG_RS13560 2884093..2884512 - 420 WP_003413190.1 A24 family peptidase -
TBFG_RS13565 2884524..2885333 - 810 WP_003413193.1 shikimate dehydrogenase -
TBFG_RS13570 2885330..2886583 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
TBFG_RS13575 2886576..2887088 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-122)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T22237 WP_003413164.1 NC_009565:2881472-2881885 [Mycobacterium tuberculosis F11]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T22237 NC_009565:2881472-2881885 [Mycobacterium tuberculosis F11]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT22237 WP_003413167.1 NC_009565:2881924-2882181 [Mycobacterium tuberculosis F11]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT22237 NC_009565:2881924-2882181 [Mycobacterium tuberculosis F11]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ26


Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References