Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3069640..3070400 Replicon chromosome
Accession NZ_CP085981
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LJY16_RS15360 Protein ID WP_000533909.1
Coordinates 3069640..3070125 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJY16_RS15365 Protein ID WP_000965886.1
Coordinates 3070113..3070400 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS15330 (3064711) 3064711..3065373 + 663 WP_000747548.1 OmpA family lipoprotein -
LJY16_RS15335 (3065592) 3065592..3066566 + 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJY16_RS15340 (3066616) 3066616..3067326 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJY16_RS15345 (3067765) 3067765..3068055 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJY16_RS15350 (3068343) 3068343..3068555 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJY16_RS15355 (3068729) 3068729..3069268 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
LJY16_RS15360 (3069640) 3069640..3070125 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LJY16_RS15365 (3070113) 3070113..3070400 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJY16_RS15370 (3070566) 3070566..3071124 - 559 Protein_2930 cysteine hydrolase -
LJY16_RS15375 (3071213) 3071213..3072415 - 1203 WP_023201740.1 MFS transporter -
LJY16_RS15380 (3072500) 3072500..3073150 + 651 WP_023993641.1 GntR family transcriptional regulator -
LJY16_RS15385 (3073269) 3073269..3073697 - 429 Protein_2933 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T222368 WP_000533909.1 NZ_CP085981:c3070125-3069640 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T222368 NZ_CP117823:c1419816-1419520 [Xylella fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT222368 WP_000965886.1 NZ_CP085981:c3070400-3070113 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT222368 NZ_CP117823:c1419516-1419211 [Xylella fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References