Detailed information of TA system TA222367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2956531..2957117
• Replicon: chromosome
• Accession: NZ_CP085981
• Organism: Salmonella enterica strain SZL 30

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A5Y4K907
• Locus tag: LJY16_RS14850
• Protein ID: WP_023202025.1
• Coordinates: 2956531..2956899 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: LJY16_RS14855
• Protein ID: WP_023993856.1
• Coordinates: 2956896..2957117 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJY16_RS14830 (2952050)	2952050..2953120	-	1071	WP_000907846.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
LJY16_RS14835 (2953122)	2953122..2953967	-	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
LJY16_RS14840 (2953964)	2953964..2954851	-	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
LJY16_RS14845 (2954956)	2954956..2956272	-	1317	WP_023993857.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
LJY16_RS14850 (2956531)	2956531..2956899	-	369	WP_023202025.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
LJY16_RS14855 (2956896)	2956896..2957117	-	222	WP_023993856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LJY16_RS14860 (2957248)	2957248..2957961	-	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
LJY16_RS14865 (2957963)	2957963..2958730	-	768	WP_000082083.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
LJY16_RS14870 (2958727)	2958727..2960004	-	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
LJY16_RS14875 (2960001)	2960001..2960927	-	927	WP_023183687.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
LJY16_RS14880 (2960987)	2960987..2962096	-	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2951313..2960004	8691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13703.01 Da
• Isoelectric Point: 6.7252

>T222367 WP_023202025.1 NZ_CP085981:c2956899-2956531 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRWHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T222367 NZ_CP117823:c1419516-1419211 [Xylella fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8152.14 Da
• Isoelectric Point: 5.0637

>AT222367 WP_023993856.1 NZ_CP085981:c2957117-2956896 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRDLADK

Nucleotide

• Length: 222 bp

>AT222367 NZ_CP117823:c1419816-1419520 [Xylella fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Structures

Toxin

• AlphaFold DB: A0A5Y4K907