Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2426485..2427145 Replicon chromosome
Accession NZ_CP085981
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag LJY16_RS12250 Protein ID WP_000244761.1
Coordinates 2426485..2426898 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJY16_RS12255 Protein ID WP_000351186.1
Coordinates 2426879..2427145 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS12230 (2422426) 2422426..2424159 - 1734 WP_149385273.1 single-stranded-DNA-specific exonuclease RecJ -
LJY16_RS12235 (2424165) 2424165..2424878 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJY16_RS12240 (2424902) 2424902..2425798 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJY16_RS12245 (2425911) 2425911..2426432 + 522 WP_001055885.1 flavodoxin FldB -
LJY16_RS12250 (2426485) 2426485..2426898 - 414 WP_000244761.1 protein YgfX Toxin
LJY16_RS12255 (2426879) 2426879..2427145 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJY16_RS12260 (2427395) 2427395..2428375 + 981 WP_023260866.1 tRNA-modifying protein YgfZ -
LJY16_RS12265 (2428491) 2428491..2429150 - 660 WP_000250289.1 hemolysin III family protein -
LJY16_RS12270 (2429314) 2429314..2429625 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJY16_RS12275 (2429783) 2429783..2431216 + 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T222366 WP_000244761.1 NZ_CP085981:c2426898-2426485 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T222366 NZ_CP117823:c1415976-1415710 [Xylella fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT222366 WP_000351186.1 NZ_CP085981:c2427145-2426879 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT222366 NZ_CP117823:c1416187-1415960 [Xylella fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTACGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References