Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2259387..2260201 Replicon chromosome
Accession NZ_CP085981
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag LJY16_RS11475 Protein ID WP_023994249.1
Coordinates 2259674..2260201 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LJY16_RS11470 Protein ID WP_000855694.1
Coordinates 2259387..2259677 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS11440 (2255337) 2255337..2255987 - 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
LJY16_RS11445 (2256443) 2256443..2256886 + 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LJY16_RS11450 (2257318) 2257318..2257767 + 450 WP_000381612.1 membrane protein -
LJY16_RS11455 (2257752) 2257752..2258099 + 348 WP_001669174.1 DUF1493 family protein -
LJY16_RS11460 (2258372) 2258372..2258698 - 327 WP_000393300.1 hypothetical protein -
LJY16_RS11465 (2258939) 2258939..2259117 + 179 Protein_2170 IS3 family transposase -
LJY16_RS11470 (2259387) 2259387..2259677 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LJY16_RS11475 (2259674) 2259674..2260201 + 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
LJY16_RS11480 (2260274) 2260274..2260491 - 218 Protein_2173 IS5/IS1182 family transposase -
LJY16_RS11485 (2260826) 2260826..2261482 + 657 WP_000420451.1 protein-serine/threonine phosphatase -
LJY16_RS11490 (2261653) 2261653..2262174 - 522 WP_023994250.1 hypothetical protein -
LJY16_RS11495 (2262333) 2262333..2264900 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2260274..2260414 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T222365 WP_023994249.1 NZ_CP085981:2259674-2260201 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T222365 NZ_CP117823:1222784-1223038 [Xylella fastidiosa]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGACTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCTCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT222365 WP_000855694.1 NZ_CP085981:2259387-2259677 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT222365 NZ_CP117823:1223035-1223370 [Xylella fastidiosa]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGATAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References