222356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 914515..915037 Replicon chromosome
Accession NZ_CP085981
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LJY16_RS04860 Protein ID WP_000221343.1
Coordinates 914515..914799 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag LJY16_RS04865 Protein ID WP_000885426.1
Coordinates 914789..915037 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS04840 (910594) 910594..912102 - 1509 WP_023993260.1 FAD-dependent oxidoreductase -
LJY16_RS04845 (912147) 912147..912635 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
LJY16_RS04850 (912828) 912828..913907 + 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LJY16_RS04855 (913955) 913955..914344 - 390 WP_023993262.1 RidA family protein -
LJY16_RS04860 (914515) 914515..914799 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJY16_RS04865 (914789) 914789..915037 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJY16_RS04870 (915189) 915189..915404 + 216 WP_023993263.1 phage protein -
LJY16_RS04875 (915394) 915394..915726 + 333 WP_000253154.1 DUF1493 family protein -
LJY16_RS04880 (916006) 916006..916200 + 195 Protein_885 hypothetical protein -
LJY16_RS04885 (916199) 916199..916645 - 447 Protein_886 helix-turn-helix domain-containing protein -
LJY16_RS04890 (917551) 917551..918459 + 909 WP_023994284.1 LysR family transcriptional regulator -
LJY16_RS04895 (918633) 918633..919613 + 981 WP_023993266.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 909157..921342 12185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T222356 WP_000221343.1 NZ_CP085981:c914799-914515 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T222356 NZ_CP117821:1275927-1276223 [Xylella fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT222356 WP_000885426.1 NZ_CP085981:c915037-914789 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT222356 NZ_CP117821:1276227-1276532 [Xylella fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References