Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 33745..34267 Replicon plasmid pSZL30.2
Accession NZ_CP085980
Organism Salmonella enterica strain SZL 30

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag LJY16_RS00200 Protein ID WP_000220560.1
Coordinates 33986..34267 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag LJY16_RS00195 Protein ID WP_000121743.1
Coordinates 33745..33996 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY16_RS00165 (LJY16_00165) 28823..29485 + 663 WP_050871575.1 division plane positioning ATPase MipZ -
LJY16_RS00170 (LJY16_00170) 29585..29866 + 282 WP_001185482.1 hypothetical protein -
LJY16_RS00175 (LJY16_00175) 29891..30868 + 978 WP_001579336.1 hypothetical protein -
LJY16_RS00180 (LJY16_00180) 30865..31221 - 357 WP_001576907.1 DNA distortion polypeptide 3 -
LJY16_RS00185 (LJY16_00185) 31358..31804 - 447 WP_001074386.1 hypothetical protein -
LJY16_RS00190 (LJY16_00190) 31829..32683 - 855 WP_001239324.1 replication initiation protein -
LJY16_RS00195 (LJY16_00195) 33745..33996 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
LJY16_RS00200 (LJY16_00200) 33986..34267 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJY16_RS00205 (LJY16_00205) 34413..34736 + 324 WP_001181903.1 hypothetical protein -
LJY16_RS00210 (LJY16_00210) 34781..35026 + 246 WP_000356546.1 hypothetical protein -
LJY16_RS00215 (LJY16_00215) 35016..35231 + 216 WP_001180116.1 hypothetical protein -
LJY16_RS00220 (LJY16_00220) 35324..35653 + 330 WP_000866648.1 hypothetical protein -
LJY16_RS00225 (LJY16_00225) 35696..35875 + 180 WP_000439078.1 hypothetical protein -
LJY16_RS00230 (LJY16_00230) 35945..36094 + 150 WP_000003880.1 hypothetical protein -
LJY16_RS00235 (LJY16_00235) 36107..36379 + 273 WP_000160399.1 hypothetical protein -
LJY16_RS00240 (LJY16_00240) 36705..37250 + 546 WP_000757693.1 DNA distortion polypeptide 1 -
LJY16_RS00245 (LJY16_00245) 37253..38419 + 1167 WP_001576909.1 MobP1 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / sul3 / ant(3'')-Ia / cmlA1 - 1..53986 53986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T222355 WP_000220560.1 NZ_CP085980:33986-34267 [Salmonella enterica]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T222355 NZ_CP117821:1195016-1195297 [Xylella fastidiosa]
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTGATACACGTCTTGGAAGCCTTGACCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT222355 WP_000121743.1 NZ_CP085980:33745-33996 [Salmonella enterica]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT222355 NZ_CP117821:1194766-1195029 [Xylella fastidiosa]
ATGTCTGCAAACGCAGTTGTCCGTGCCCGCGTTGACGCGCACATCAAAGAAGAAGCATCAACCGTGCTGGCGACGATGGG
CCTAAGCGTGTCTGATGCGTTCCGTATGATGCTGACCCGCATTGCCCGCGAGAAGGCGCTGCCGTTCGAGCCGCTGGTGC
CGAACGAAACTACCATCGCAGCCATGCGTGAAGCCCGTGCTGGTCACCTCAAGAGCTTTGATAGTATTGAGGCGCTCATG
GCGGACTTGCATGCGGAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References