Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 1858150..1858811 Replicon chromosome
Accession NZ_CP085978
Organism Mycobacterium avium subsp. avium strain FDAARGOS_1606

Toxin (Protein)


Gene name vapC Uniprot ID A0A049E7F1
Locus tag LK466_RS08455 Protein ID WP_023879930.1
Coordinates 1858150..1858554 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A049EBE1
Locus tag LK466_RS08460 Protein ID WP_009976405.1
Coordinates 1858551..1858811 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK466_RS08430 (LK466_08430) 1853329..1854498 + 1170 WP_009976416.1 acyl-CoA dehydrogenase -
LK466_RS08435 (LK466_08435) 1854487..1855017 - 531 WP_011724637.1 TetR/AcrR family transcriptional regulator -
LK466_RS08440 (LK466_08440) 1855138..1855683 - 546 WP_009976412.1 carboxymuconolactone decarboxylase family protein -
LK466_RS08445 (LK466_08445) 1855680..1856201 - 522 WP_227975118.1 carboxymuconolactone decarboxylase family protein -
LK466_RS08450 (LK466_08450) 1856438..1858003 + 1566 WP_029248458.1 serine/threonine-protein kinase -
LK466_RS08455 (LK466_08455) 1858150..1858554 - 405 WP_023879930.1 type II toxin-antitoxin system VapC family toxin Toxin
LK466_RS08460 (LK466_08460) 1858551..1858811 - 261 WP_009976405.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LK466_RS08465 (LK466_08465) 1858992..1859444 - 453 WP_029248457.1 VOC family protein -
LK466_RS08470 (LK466_08470) 1859610..1860878 + 1269 WP_227975119.1 cytochrome P450 -
LK466_RS08475 (LK466_08475) 1861080..1862540 - 1461 WP_009976402.1 serine/threonine-protein kinase -
LK466_RS08480 (LK466_08480) 1862735..1863397 - 663 WP_009976400.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14329.33 Da        Isoelectric Point: 4.5860

>T222352 WP_023879930.1 NZ_CP085978:c1858554-1858150 [Mycobacterium avium subsp. avium]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 405 bp

>T222352 NZ_CP117821:352912-353214 [Xylella fastidiosa]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9495.81 Da        Isoelectric Point: 11.4633

>AT222352 WP_009976405.1 NZ_CP085978:c1858811-1858551 [Mycobacterium avium subsp. avium]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT222352 NZ_CP117821:352549-352824 [Xylella fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A049E7F1

Antitoxin

Source ID Structure
AlphaFold DB A0A049EBE1

References