Detailed information of TA system TA222351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 1563044..1564042
• Replicon: chromosome
• Accession: NZ_CP085978
• Organism: Mycobacterium avium subsp. avium strain FDAARGOS_1606

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: LK466_RS07170
• Protein ID: WP_227975094.1
• Coordinates: 1563044..1563622 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A049EEK5
• Locus tag: LK466_RS07175
• Protein ID: WP_009976725.1
• Coordinates: 1563653..1564042 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK466_RS07145 (LK466_07145)	1559039..1559968	-	930	Protein_1419	sigma-70 family RNA polymerase sigma factor	-
LK466_RS07150 (LK466_07150)	1560137..1560487	+	351	WP_003878038.1	DoxX family protein	-
LK466_RS07155 (LK466_07155)	1560501..1561301	-	801	WP_031354786.1	nuclear transport factor 2 family protein	-
LK466_RS07160 (LK466_07160)	1561301..1561861	-	561	WP_155251422.1	pyrazinamidase PncA	-
LK466_RS07165 (LK466_07165)	1561972..1563039	+	1068	WP_003876748.1	DoxX family protein	-
LK466_RS07170 (LK466_07170)	1563044..1563622	-	579	WP_227975094.1	zeta toxin family protein	Toxin
LK466_RS07175 (LK466_07175)	1563653..1564042	-	390	WP_009976725.1	hypothetical protein	Antitoxin
LK466_RS07180 (LK466_07180)	1564123..1564617	-	495	WP_010949355.1	gluconokinase	-
LK466_RS07185 (LK466_07185)	1564614..1566611	-	1998	WP_009976721.1	phosphotransferase	-
LK466_RS07190 (LK466_07190)	1566630..1568147	-	1518	WP_227975095.1	carboxylesterase/lipase family protein	-
LK466_RS07195 (LK466_07195)	1568226..1568906	+	681	WP_023861532.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21006.13 Da
• Isoelectric Point: 10.6678

>T222351 WP_227975094.1 NZ_CP085978:c1563622-1563044 [Mycobacterium avium subsp. avium]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRARAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Nucleotide

• Length: 579 bp

>T222351 NZ_CP117821:352257-352538 [Xylella fastidiosa]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTCAAGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13598.04 Da
• Isoelectric Point: 5.6717

>AT222351 WP_009976725.1 NZ_CP085978:c1564042-1563653 [Mycobacterium avium subsp. avium]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Nucleotide

• Length: 390 bp

>AT222351 NZ_CP117821:352549-352824 [Xylella fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Structures

Antitoxin

• AlphaFold DB: A0A049EEK5