222350

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2734149..2735147 Replicon chromosome
Accession NZ_CP085977
Organism Mycobacterium avium subsp. avium strain FDAARGOS_1607

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag LK460_RS12930 Protein ID WP_003876749.1
Coordinates 2734569..2735147 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A049EEK5
Locus tag LK460_RS12925 Protein ID WP_009976725.1
Coordinates 2734149..2734538 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK460_RS12905 (LK460_12905) 2729285..2729965 - 681 WP_023861532.1 hypothetical protein -
LK460_RS12910 (LK460_12910) 2730044..2731561 + 1518 WP_009976720.1 carboxylesterase/lipase family protein -
LK460_RS12915 (LK460_12915) 2731580..2733577 + 1998 WP_009976721.1 phosphotransferase -
LK460_RS12920 (LK460_12920) 2733574..2734068 + 495 WP_009976723.1 gluconokinase -
LK460_RS12925 (LK460_12925) 2734149..2734538 + 390 WP_009976725.1 hypothetical protein Antitoxin
LK460_RS12930 (LK460_12930) 2734569..2735147 + 579 WP_003876749.1 zeta toxin family protein Toxin
LK460_RS12935 (LK460_12935) 2735152..2736219 - 1068 WP_003876748.1 DoxX family protein -
LK460_RS12940 (LK460_12940) 2736330..2736890 + 561 WP_155251422.1 pyrazinamidase PncA -
LK460_RS12945 (LK460_12945) 2736890..2737690 + 801 WP_009976729.1 nuclear transport factor 2 family protein -
LK460_RS12950 (LK460_12950) 2737704..2738054 - 351 WP_003878038.1 DoxX family protein -
LK460_RS12955 (LK460_12955) 2738223..2739152 + 930 Protein_2556 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T222350 WP_003876749.1 NZ_CP085977:2734569-2735147 [Mycobacterium avium subsp. avium]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T222350 NZ_CP117820:c2524766-2524338 [Xylella fastidiosa]
ATGATTGTCTTGGATACCAATGTTGTTTCCGAAGCAATGAAACCCGAGCCGGATGCAGCAGTCCGAACCTGGCTCAACGA
GCAGATGAGCGTCACGTTGTACCTATCCAGTGTGACGTTATCTGAACTGTTGTTTGGAATCGCAGTGTTGCCCACAAGTA
AGCGCAAGGACATGTTGGCTCGTACCCTTGATGGCTTGCTTGATCTGTTCAATGAACGGGTGTTGCCGTTCGATACGGAC
GCGGCACGCCACTATGCTGAACTGGCAGTGAAAGCGAGAAACAATGGGCGCGGCTTTCCCACACCGGATGGCTATATCGC
GGCAATTGCTGCATCACGAGGTTACATAGTGGCTTCCCGCGACACCTCAGCCTATGAGTCAAGTGGTGTGCAAGTCATCA
ATCCGTGGCAATACAGCAAACAAACATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13598.04 Da        Isoelectric Point: 5.6717

>AT222350 WP_009976725.1 NZ_CP085977:2734149-2734538 [Mycobacterium avium subsp. avium]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT222350 NZ_CP117820:c2525021-2524767 [Xylella fastidiosa]
ATGGCCATGTTGACAGTGCGTAATTTGCCTGATGAAGTCCATCGCGCCTTGCGGGTTCGAGCCGCCACACACGGCCGCAG
TACAGAAGCGGAAGTACGTGAGATTTTAACGAACATAGTCAAGCCGGATGAGCGTGTTCGCATTGGCGATGCCTTGGCTA
TCCTGGGACGCGAGATCGGACTAAATAACGAGGATTTCACGACCTTTGATAAGGTGCGAGACAAGACGCAGGCCGAGCCG
ATGAGATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2W6B4

Antitoxin

Source ID Structure
AlphaFold DB A0A049EEK5

References