Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-PHD |
| Location | 2219441..2220102 | Replicon | chromosome |
| Accession | NZ_CP085977 | ||
| Organism | Mycobacterium avium subsp. avium strain FDAARGOS_1607 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A049E7F1 |
| Locus tag | LK460_RS10460 | Protein ID | WP_023879930.1 |
| Coordinates | 2219698..2220102 (+) | Length | 135 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A049EBE1 |
| Locus tag | LK460_RS10455 | Protein ID | WP_009976405.1 |
| Coordinates | 2219441..2219701 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK460_RS10435 (LK460_10435) | 2214855..2215517 | + | 663 | WP_009976400.1 | TetR/AcrR family transcriptional regulator | - |
| LK460_RS10440 (LK460_10440) | 2215712..2217172 | + | 1461 | WP_009976402.1 | serine/threonine-protein kinase | - |
| LK460_RS10445 (LK460_10445) | 2217374..2218642 | - | 1269 | WP_023884275.1 | cytochrome P450 | - |
| LK460_RS10450 (LK460_10450) | 2218808..2219260 | + | 453 | WP_029248457.1 | VOC family protein | - |
| LK460_RS10455 (LK460_10455) | 2219441..2219701 | + | 261 | WP_009976405.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| LK460_RS10460 (LK460_10460) | 2219698..2220102 | + | 405 | WP_023879930.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LK460_RS10465 (LK460_10465) | 2220249..2221814 | - | 1566 | WP_029248458.1 | serine/threonine-protein kinase | - |
| LK460_RS10470 (LK460_10470) | 2222051..2222572 | + | 522 | WP_009976411.1 | carboxymuconolactone decarboxylase family protein | - |
| LK460_RS10475 (LK460_10475) | 2222569..2223114 | + | 546 | WP_009976412.1 | carboxymuconolactone decarboxylase family protein | - |
| LK460_RS10480 (LK460_10480) | 2223235..2223765 | + | 531 | WP_011724637.1 | TetR/AcrR family transcriptional regulator | - |
| LK460_RS10485 (LK460_10485) | 2223754..2224923 | - | 1170 | WP_009976416.1 | acyl-CoA dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14329.33 Da Isoelectric Point: 4.5860
>T222349 WP_023879930.1 NZ_CP085977:2219698-2220102 [Mycobacterium avium subsp. avium]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV
Download Length: 405 bp
>T222349 NZ_CP117820:c1889302-1888691 [Xylella fastidiosa]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGTCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAAGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTCCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGTGGATTGGC
TAGTATCATCCGCGAAGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGTCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAAGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTCCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGTGGATTGGC
TAGTATCATCCGCGAAGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9495.81 Da Isoelectric Point: 11.4633
>AT222349 WP_009976405.1 NZ_CP085977:2219441-2219701 [Mycobacterium avium subsp. avium]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
Download Length: 261 bp
>AT222349 NZ_CP117820:c1889487-1889299 [Xylella fastidiosa]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAAGCCGTTGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAAGCCGTTGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A049E7F1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A049EBE1 |