222345

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 4549415..4549911 Replicon chromosome
Accession NZ_CP085974
Organism Gordonia otitidis strain FDAARGOS_1600

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LK459_RS20765 Protein ID WP_265416883.1
Coordinates 4549615..4549911 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LK459_RS20760 Protein ID WP_007238913.1
Coordinates 4549415..4549582 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK459_RS20740 (LK459_20740) 4544540..4546045 - 1506 WP_227920468.1 MFS transporter -
LK459_RS20745 (LK459_20745) 4546263..4547525 + 1263 WP_227920471.1 DUF2235 domain-containing protein -
LK459_RS20750 (LK459_20750) 4547655..4548017 + 363 WP_227920472.1 metalloregulator ArsR/SmtB family transcription factor -
LK459_RS20755 (LK459_20755) 4548014..4549087 + 1074 WP_227920474.1 ACR3 family arsenite efflux transporter -
LK459_RS20760 (LK459_20760) 4549415..4549582 + 168 WP_007238913.1 antitoxin MazE family protein Antitoxin
LK459_RS20765 (LK459_20765) 4549615..4549911 + 297 WP_265416883.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LK459_RS20770 (LK459_20770) 4549801..4550286 - 486 WP_227924028.1 hypothetical protein -
LK459_RS20775 (LK459_20775) 4550480..4551070 - 591 WP_227920478.1 hypothetical protein -
LK459_RS20780 (LK459_20780) 4551653..4552168 - 516 WP_227920481.1 ATP-binding protein -
LK459_RS20785 (LK459_20785) 4552260..4553963 - 1704 WP_227920482.1 FUSC family protein -
LK459_RS20790 (LK459_20790) 4553997..4554551 - 555 WP_227923918.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-93)

Antitoxin

Antitoxin MazE-like

(1-53)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10733.39 Da        Isoelectric Point: 7.0118

>T222345 WP_265416883.1 NZ_CP085974:4549615-4549911 [Gordonia otitidis]
VYASNPRPAVIVQDDLFDSTLSVVVAPMTSHLVDAPLLRIRIPGDRGAMSGLDRDSDVMVDKLTAVRRSNVQTRVGRLTS
EQLVEVERSLMAFLGLAR

Download         Length: 297 bp

>T222345 NZ_CP117820:1382430-1382696 [Xylella fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCACGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAATCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGTGGCT
TTTGGCGTTATCGTGTTGGTGATTTTCGGGTCGTCTGCGACATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGCGAGATTTACCGATAG

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6160.83 Da        Isoelectric Point: 4.0385

>AT222345 WP_007238913.1 NZ_CP085974:4549415-4549582 [Gordonia otitidis]
MRERGLRPLQVWVPDVRTPEFAVQAHKQSVLLAEADADGDEQEFVEAVAAPWDDA

Download         Length: 168 bp

>AT222345 NZ_CP117820:1382219-1382446 [Xylella fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTTAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAGCGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGACGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References