Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3780471..3781107 | Replicon | chromosome |
| Accession | NZ_CP085972 | ||
| Organism | Bordetella parapertussis strain FDAARGOS_1540 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q7W5Z1 |
| Locus tag | LK435_RS18045 | Protein ID | WP_010928914.1 |
| Coordinates | 3780925..3781107 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q7W5Z0 |
| Locus tag | LK435_RS18040 | Protein ID | WP_010928915.1 |
| Coordinates | 3780471..3780863 (-) | Length | 131 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK435_RS18005 (LK435_18005) | 3776127..3776553 | - | 427 | Protein_3557 | OB-fold domain-containing protein | - |
| LK435_RS18010 (LK435_18010) | 3776557..3777729 | - | 1173 | WP_010928918.1 | thiolase domain-containing protein | - |
| LK435_RS18015 (LK435_18015) | 3777796..3778155 | - | 360 | WP_010928917.1 | hypothetical protein | - |
| LK435_RS18020 (LK435_18020) | 3778190..3779164 | - | 975 | WP_010928916.1 | tripartite tricarboxylate transporter substrate binding protein | - |
| LK435_RS18025 (LK435_18025) | 3779217..3779387 | - | 171 | WP_226376428.1 | hypothetical protein | - |
| LK435_RS18030 (LK435_18030) | 3779361..3779432 | + | 72 | Protein_3562 | LysR family transcriptional regulator | - |
| LK435_RS18035 (LK435_18035) | 3779470..3780198 | + | 729 | WP_226376427.1 | LysR family substrate-binding domain-containing protein | - |
| LK435_RS18040 (LK435_18040) | 3780471..3780863 | - | 393 | WP_010928915.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LK435_RS18045 (LK435_18045) | 3780925..3781107 | - | 183 | WP_010928914.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LK435_RS18050 (LK435_18050) | 3781656..3782876 | - | 1221 | WP_010928912.1 | ISL3-like element IS1001 family transposase | - |
| LK435_RS18060 (LK435_18060) | 3783451..3784638 | - | 1188 | WP_010928911.1 | MFS transporter | - |
| LK435_RS18065 (LK435_18065) | 3784856..3785533 | - | 678 | WP_010928910.1 | HAD-IA family hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3781656..3782876 | 1220 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6572.69 Da Isoelectric Point: 10.9062
>T222342 WP_010928914.1 NZ_CP085972:c3781107-3780925 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK
Download Length: 183 bp
>T222342 NZ_CP117820:c1028714-1028235 [Xylella fastidiosa]
ATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTTGATGAATTCAATTGCGGTGAGCCATCGCTGGATGA
TTGGCTTAAACGACGCGCACTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTGGTTATCGATGCCAACCAATACG
TGCTTGGGTACTACGCTTTGGCAGCCGGGGCTGTAGCGCATCAAGAGGCCACCCGTGCTATCCGACGTAACATGCCTGAT
CCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTGGATACTCGTGCTCAAGGCATCAAACTCGGTGCGGCCTTGCTTAA
AGATACGGTAACTCGTGTGCAGTCCATTGCAGAGAACGCCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACGAGCGCG
CAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAATTCTAG
ATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTTGATGAATTCAATTGCGGTGAGCCATCGCTGGATGA
TTGGCTTAAACGACGCGCACTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTGGTTATCGATGCCAACCAATACG
TGCTTGGGTACTACGCTTTGGCAGCCGGGGCTGTAGCGCATCAAGAGGCCACCCGTGCTATCCGACGTAACATGCCTGAT
CCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTGGATACTCGTGCTCAAGGCATCAAACTCGGTGCGGCCTTGCTTAA
AGATACGGTAACTCGTGTGCAGTCCATTGCAGAGAACGCCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACGAGCGCG
CAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAATTCTAG
Antitoxin
Download Length: 131 a.a. Molecular weight: 14058.82 Da Isoelectric Point: 4.2876
>AT222342 WP_010928915.1 NZ_CP085972:c3780863-3780471 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA
Download Length: 393 bp
>AT222342 NZ_CP117820:c1028989-1028717 [Xylella fastidiosa]
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTTAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTAATGCGCCACAAGACACCAATCCAGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCAGCAATACGTGA
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTTAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTAATGCGCCACAAGACACCAATCCAGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCAGCAATACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|