Detailed information of TA system TA222341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 881770..882431
• Replicon: chromosome
• Accession: NZ_CP085972
• Organism: Bordetella parapertussis strain FDAARGOS_1540

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: LK435_RS04320
• Protein ID: WP_003812073.1
• Coordinates: 882006..882431 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LK435_RS04315
• Protein ID: WP_003812071.1
• Coordinates: 881770..882009 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK435_RS04280 (LK435_04280)	876805..877608	-	804	WP_003812055.1	family 1 encapsulin nanocompartment shell protein	-
LK435_RS04285 (LK435_04285)	877605..878651	-	1047	WP_010928022.1	Dyp-type peroxidase	-
LK435_RS04290 (LK435_04290)	878729..879289	-	561	WP_010928021.1	DUF488 domain-containing protein	-
LK435_RS04295 (LK435_04295)	879286..879519	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
LK435_RS04300 (LK435_04300)	879600..880112	-	513	WP_003812062.1	redoxin domain-containing protein	-
LK435_RS04305 (LK435_04305)	880171..880716	-	546	WP_010928020.1	peroxidase-related enzyme	-
LK435_RS04310 (LK435_04310)	880854..881696	+	843	WP_010928019.1	AraC family transcriptional regulator	-
LK435_RS04315 (LK435_04315)	881770..882009	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
LK435_RS04320 (LK435_04320)	882006..882431	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
LK435_RS04325 (LK435_04325)	882541..883005	+	465	WP_003812075.1	MarR family transcriptional regulator	-
LK435_RS04330 (LK435_04330)	883103..884608	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
LK435_RS04335 (LK435_04335)	885107..885619	+	513	WP_010928017.1	hypothetical protein	-
LK435_RS04340 (LK435_04340)	885640..886617	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T222341 WP_003812073.1 NZ_CP085972:882006-882431 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T222341 NZ_CP117820:c889431-889108 [Xylella fastidiosa]
ATGATTCAACGTGGCGACCTTGTAACAGTTTCCCTACAAGGCGACTACGGCAAGCCTAGACCAGCGTTGATCGTTCAATC
AGACCTTCTAACGGAGTTAGATAGTGTCGTACTGTGTCCGGTCACGAGCGACCTGCGAAATGCGATATTTCGTGTCACCG
TTGAACCAACCGCGGCCAATGGTTTACGGACACTGTCGCAGGTCATGGTAGATAAAATTTCAACACTACCACGTAACAAA
ATCAGCGAACCTTTTGGACGTCTCAATGACGAGAGAATGAAAGCAATAGAAAGAGCATTGTTACTAATTATTGGTATCAT
TTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT222341 WP_003812071.1 NZ_CP085972:881770-882009 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT222341 NZ_CP117820:c889649-889428 [Xylella fastidiosa]
ATGACATCAACTCACAGACCAGACAGCAAAATAGTTCACCACAGGGAACAAATGCGCGCAGCGGGATTGCGTCCTATGCA
GCTCTGGGTACCGGATACGCGCACACCGGAATTCGCTGCTGAAATTCGAAGCCAGTGCCGCGCCTTGAAGGGCGACCAGG
CAGAAGCCGACGCTTTACGCTTCACAGAAAAAACCATGACCCATATTGAAGGTTGGAAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5