22234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2415754..2416283 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag TBFG_RS11325 Protein ID WP_003411124.1
Coordinates 2415754..2416071 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag TBFG_RS11330 Protein ID WP_003411127.1
Coordinates 2416068..2416283 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS11295 2410891..2411967 + 1077 WP_003411110.1 hypothetical protein -
TBFG_RS11300 2411964..2412245 + 282 WP_003411112.1 hypothetical protein -
TBFG_RS11305 2412281..2413354 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
TBFG_RS11310 2413359..2413889 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
TBFG_RS11315 2413937..2415283 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
TBFG_RS11325 2415754..2416071 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBFG_RS11330 2416068..2416283 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
TBFG_RS11335 2416538..2417596 + 1059 WP_003411129.1 hypothetical protein -
TBFG_RS11340 2417726..2418082 - 357 WP_003411130.1 hypothetical protein -
TBFG_RS11345 2418177..2418959 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
TBFG_RS11350 2419227..2419517 - 291 WP_003900476.1 YggT family protein -
TBFG_RS11355 2419679..2420335 - 657 WP_003411133.1 cell division protein SepF -
TBFG_RS11360 2420401..2421177 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T22234 WP_003411124.1 NC_009565:c2416071-2415754 [Mycobacterium tuberculosis F11]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T22234 NC_009565:c2416071-2415754 [Mycobacterium tuberculosis F11]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT22234 WP_003411127.1 NC_009565:c2416283-2416068 [Mycobacterium tuberculosis F11]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT22234 NC_009565:c2416283-2416068 [Mycobacterium tuberculosis F11]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References