Detailed information of TA system TA222338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2918988..2919624
• Replicon: chromosome
• Accession: NZ_CP085971
• Organism: Bordetella parapertussis strain FDAARGOS_1541

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: LK409_RS13815
• Protein ID: WP_010928914.1
• Coordinates: 2918988..2919170 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: LK409_RS13820
• Protein ID: WP_010928915.1
• Coordinates: 2919232..2919624 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK409_RS13795 (LK409_13795)	2914562..2915239	+	678	WP_010928910.1	HAD-IA family hydrolase	-
LK409_RS13800 (LK409_13800)	2915457..2916644	+	1188	WP_010928911.1	MFS transporter	-
LK409_RS13810 (LK409_13810)	2917219..2918439	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
LK409_RS13815 (LK409_13815)	2918988..2919170	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
LK409_RS13820 (LK409_13820)	2919232..2919624	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LK409_RS13825 (LK409_13825)	2919897..2920625	-	729	WP_226376427.1	LysR family substrate-binding domain-containing protein	-
LK409_RS13830 (LK409_13830)	2920663..2920740	-	78	Protein_2734	LysR family transcriptional regulator	-
LK409_RS13835 (LK409_13835)	2920708..2920878	+	171	WP_226376428.1	hypothetical protein	-
LK409_RS13840 (LK409_13840)	2920931..2921905	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
LK409_RS13845 (LK409_13845)	2921940..2922299	+	360	WP_010928917.1	hypothetical protein	-
LK409_RS13850 (LK409_13850)	2922366..2923538	+	1173	WP_010928918.1	thiolase domain-containing protein	-
LK409_RS13855 (LK409_13855)	2923542..2923968	+	427	Protein_2739	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2917219..2918439	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T222338 WP_010928914.1 NZ_CP085971:2918988-2919170 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T222338 NZ_CP117820:c738988-738722 [Xylella fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCACGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAATCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGTGGCT
TTTGGCGTTATCGTGTTGGTGATTTTCGGGTCGTCTGCGACATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGCGAGATTTACCGATAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT222338 WP_010928915.1 NZ_CP085971:2919232-2919624 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT222338 NZ_CP117820:c739199-738972 [Xylella fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTTAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAGCGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGACGTGAGGAAAACGCTTGGCCTGGACGATTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0