Detailed information of TA system TA222336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1762935..1763529
• Replicon: chromosome
• Accession: NZ_CP085971
• Organism: Bordetella parapertussis strain FDAARGOS_1541

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: LK409_RS08415
• Protein ID: WP_010928352.1
• Coordinates: 1763347..1763529 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: LK409_RS08410
• Protein ID: WP_010928351.1
• Coordinates: 1762935..1763324 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK409_RS08385 (LK409_08385)	1758778..1759818	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
LK409_RS08390 (LK409_08390)	1759953..1760969	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
LK409_RS08395 (LK409_08395)	1760991..1761848	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
LK409_RS08400 (LK409_08400)	1761893..1762669	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
LK409_RS08410 (LK409_08410)	1762935..1763324	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LK409_RS08415 (LK409_08415)	1763347..1763529	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
LK409_RS08420 (LK409_08420)	1763973..1764635	+	663	WP_226376529.1	gluconate 2-dehydrogenase subunit 3 family protein	-
LK409_RS08425 (LK409_08425)	1764639..1766408	+	1770	WP_010928353.1	GMC family oxidoreductase	-
LK409_RS08430 (LK409_08430)	1766419..1767774	+	1356	WP_003809657.1	cytochrome c	-
LK409_RS08435 (LK409_08435)	1767786..1768526	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T222336 WP_010928352.1 NZ_CP085971:c1763529-1763347 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T222336 NZ_CP117818:c2666507-2665656 [Legionella pneumophila]
ATGACAAAAAATATTGGTGAATCCTTACGCTCACGTTTGAAAAATATAGCCGTTAAAGAAGGTTCTGACTTTAATGCAGT
CTTAACCCGTTATGGTCTAGAGCGCATGTTATATAGAATTGGGGAATCAGAATATTCTAATCAGTTTTTGTTAAAAGGTG
CTTTATTGTTTAACCTATGGTACGACATGCCCCATCGTCCAACTAAAGATATTGATTTATTGGGGTTTGGTGATAATGAT
ATGGCGTATATTAAACAAACGTTCAGTAAAATTTGTAGCATCTCAGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTAAACACTATAAAAAAAGATGGTGGTTACACGGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAGGCAAAAA
TTAAAATACAAATTGATATTGGTTATGGTGATGCAGTTACTCCCCGGCCAATAGACGCTCATTATCCTGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATTCGCACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTCTTGGG
CATGGCGAATAGCCGATTAAAAGACTATTTGGATCTTTATGTATTATTAAATAACGAGCAGTTGGATAATCAAATCTTGG
CTAAAGCCATACAGGCTACGTTTAATCGCCGAGGGATGACTCTCCCTGAAGCGCTGCCTATTGGCCTGACTGATGAATTC
GCCAATGACCCAACCAGAGAATCAATGTGGAAAGCATTTTTGAGAAAGAATGAACTAGAGCAGAAGTCATTAACAGAAGT
TATTGTTGTGATCAGAAATTTGATCCTAATGCCATTTGCTTTGGCAAAGTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT222336 WP_010928351.1 NZ_CP085971:c1763324-1762935 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT222336 NZ_CP117818:c2667112-2666504 [Legionella pneumophila]
ATGAAGACTGAAGCTACCTATAAACAAAAAGTACTCCAGATGGCTAGTAAAACGGGCATTGTTAGAATGTCCGATCTAAC
CAAAAGAGGGATCACTAGAGCGACCATATCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTTCTGGGCTCTATT
GCTTGCCGGAGACTGAGTTTTCAGAAAAAGAAAGCCTGATTATTATAGCAAGCCGAGTACCTAAAGCAGTGTTTTGCCTA
CTAACTGCTTTGCAGATACATGAGCTAACAACACAGCTACCACGAAAAGTATGGATAGCTATGCCAAAAGGCAGTCATAC
GCCAAAAATGGATTATCCACCGGTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGCGAAGGAATTGAAATTATAGACT
CAGATAATATTAAACTAAGGGTGTATAATCTGGCCAAGACAATTGCAGATTCTTTCAAACACCGCAATAAAATTGGCCTT
GACGTGGCCATTGAAGCGCTCAAAGAAGCTTATTCAAAAAATAAAGTAACAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7