Detailed information of TA system TA222334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1042109..1042770
• Replicon: chromosome
• Accession: NZ_CP085971
• Organism: Bordetella parapertussis strain FDAARGOS_1541

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: LK409_RS04935
• Protein ID: WP_003812073.1
• Coordinates: 1042109..1042534 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LK409_RS04940
• Protein ID: WP_003812071.1
• Coordinates: 1042531..1042770 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK409_RS04915 (LK409_04915)	1037923..1038900	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
LK409_RS04920 (LK409_04920)	1038921..1039433	-	513	WP_010928017.1	hypothetical protein	-
LK409_RS04925 (LK409_04925)	1039932..1041437	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
LK409_RS04930 (LK409_04930)	1041535..1041999	-	465	WP_003812075.1	MarR family transcriptional regulator	-
LK409_RS04935 (LK409_04935)	1042109..1042534	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
LK409_RS04940 (LK409_04940)	1042531..1042770	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
LK409_RS04945 (LK409_04945)	1042844..1043686	-	843	WP_010928019.1	AraC family transcriptional regulator	-
LK409_RS04950 (LK409_04950)	1043824..1044369	+	546	WP_010928020.1	peroxidase-related enzyme	-
LK409_RS04955 (LK409_04955)	1044428..1044940	+	513	WP_003812062.1	redoxin domain-containing protein	-
LK409_RS04960 (LK409_04960)	1045021..1045254	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
LK409_RS04965 (LK409_04965)	1045251..1045811	+	561	WP_010928021.1	DUF488 domain-containing protein	-
LK409_RS04970 (LK409_04970)	1045889..1046935	+	1047	WP_010928022.1	Dyp-type peroxidase	-
LK409_RS04975 (LK409_04975)	1046932..1047735	+	804	WP_003812055.1	family 1 encapsulin nanocompartment shell protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T222334 WP_003812073.1 NZ_CP085971:c1042534-1042109 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T222334 NZ_CP117817:c2691368-2690517 [Legionella pneumophila]
ATGACAAAAAATATTGGTGAATCCTTACGCTCACGTTTGAAAAATATAGCCGTTAAAGAAGGTTCTGACTTTAATGCAGT
CTTAACCCGTTATGGTCTAGAGCGCATGTTATATAGAATTGGGGAATCAGAATATTCTAATCAGTTTTTGTTAAAAGGTG
CTTTATTGTTTAACCTATGGTACGACATGCCCCATCGTCCAACTAAAGATATTGATTTATTGGGGTTTGGTGATAATGAT
ATGGCGTATATTAAACAAACGTTCAGTAAAATTTGTAGCATCTCAGCAGATGATGGAATAAGTTTTCTGTCTGAATCAGT
GACGGTAAACACTATAAAAAAAGATGGTGGTTACACGGGAGCAAGAGTTGAGTTATTTGGGGAATTGGCGAAGGCAAAAA
TTAAAATACAAATTGATATTGGTTATGGTGATGCAGTTACTCCCCGGCCAATAGACGCTCATTATCCTGTACTTCTTAGT
GATCTTCCTGCCCCTAAAATTCGCACTTATCCAATTTATACGGTAATTGCAGAAAAGCTGCACGCAATTGCATTCTTGGG
CATGGCGAATAGCCGATTAAAAGACTATTTGGATCTTTATGTATTATTAAATAACGAGCAGTTGGATAATCAAATCTTGG
CTAAAGCCATACAGGCTACGTTTAATCGCCGAGGGATGACTCTCCCTGAAGCGCTGCCTATTGGCCTGACTGATGAATTC
GCCAATGACCCAACCAGAGAATCAATGTGGAAAGCATTTTTGAGAAAGAATGAACTAGAGCAGAAGTCATTAACAGAAGT
TATTGTTGTGATCAGAAATTTGATCCTAATGCCATTTGCTTTGGCAAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT222334 WP_003812071.1 NZ_CP085971:c1042770-1042531 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT222334 NZ_CP117817:c2691973-2691365 [Legionella pneumophila]
ATGAAGACTGAAGCTACCTATAAACAAAAAGTACTCCAGATGGCTAGTAAAACGGGCATTGTTAGAATGTCCGATCTAAC
CAAAAGAGGGATCACTAGAGCGACCATATCAAGGCTTGTTAGCGAAAACAAACTTGAAAAACTCGCTTCTGGGCTCTATT
GCTTGCCGGAGACTGAGTTTTCAGAAAAAGAAAGCCTGATTATTATAGCAAGCCGAGTACCTAAAGCAGTGTTTTGCCTA
CTAACTGCTTTGCAGATACATGAGCTAACAACACAGCTACCACGAAAAGTATGGATAGCTATGCCAAAAGGCAGTCATAC
GCCAAAAATGGATTATCCACCGGTAAAAATGGTGCAATATTCAGATGAAGCCTTTAGCGAAGGAATTGAAATTATAGACT
CAGATAATATTAAACTAAGGGTGTATAATCTGGCCAAGACAATTGCAGATTCTTTCAAACACCGCAATAAAATTGGCCTT
GACGTGGCCATTGAAGCGCTCAAAGAAGCTTATTCAAAAAATAAAGTAACAGTTGATGAACTATGGCATTATGCGAAAAT
TTGTCGCGTTGCAAACGTAATGCGTCCTTATATTGAGGCAATTCAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5