Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 383875..385619 Replicon chromosome
Accession NZ_CP085966
Organism Burkholderia dolosa strain FDAARGOS_1544

Toxin (Protein)


Gene name doc Uniprot ID A0A892IG78
Locus tag LK423_RS01750 Protein ID WP_006766124.1
Coordinates 383875..384765 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A892IEP8
Locus tag LK423_RS01755 Protein ID WP_006766123.1
Coordinates 384762..385619 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK423_RS01720 (LK423_01720) 379252..380331 - 1080 WP_035974291.1 porin -
LK423_RS01725 (LK423_01725) 380776..381093 + 318 WP_006766129.1 non-heme iron oxygenase ferredoxin subunit -
LK423_RS01730 (LK423_01730) 381095..381406 + 312 WP_006766128.1 hypothetical protein -
LK423_RS01735 (LK423_01735) 381468..382538 + 1071 WP_006766127.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
LK423_RS01740 (LK423_01740) 382531..383301 + 771 WP_035975317.1 SDR family oxidoreductase -
LK423_RS01745 (LK423_01745) 383329..383856 + 528 WP_035975316.1 cupin domain-containing protein -
LK423_RS01750 (LK423_01750) 383875..384765 + 891 WP_006766124.1 alpha/beta fold hydrolase Toxin
LK423_RS01755 (LK423_01755) 384762..385619 + 858 WP_006766123.1 IclR family transcriptional regulator Antitoxin
LK423_RS01760 (LK423_01760) 385699..386496 + 798 WP_035974289.1 SDR family oxidoreductase -
LK423_RS01765 (LK423_01765) 386489..388156 + 1668 WP_035974287.1 thiamine pyrophosphate-binding protein -
LK423_RS01770 (LK423_01770) 388149..388976 + 828 WP_006766122.1 aspartate dehydrogenase -
LK423_RS01775 (LK423_01775) 389068..390558 + 1491 WP_035974286.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-276)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30188.38 Da        Isoelectric Point: 6.6302

>T222328 WP_006766124.1 NZ_CP085966:383875-384765 [Burkholderia dolosa]
MTVIEKRERAAAFAALLEQFPEQRCAAGAAGTIGYREAGAQQADRALPVVLLHGIGSGAASWVRQLDALGAVRRVLAWDA
PGYGASTPVRAASPVAADYAAALDAWLDALGIERCVVVGHSLGAIVAGGMVSAMPARIAGLLLISPAGGYGSASADTRNA
RRDARLAMLAALGPAGLAEQRSGNMLSGFASDDARAWVRWNMARIVPDGYAQATHLLANADLAADVAGFAGHAAVAVGAN
DAITPPAACERIAAALGVELQVVPQAGHAGYVEAPAIYSALIDAFCRSCDTQRRPA

Download         Length: 891 bp

>T222328 NZ_CP117812:2339326-2339736 [Lentisphaera profundi]
ATGATTGATGATGTGAAATTTAATAAGCTCAATACGATTGAGCGCTGCCTCAAACGAATTGATGAAGAGTATCAGAATTC
GCACGAACGTTATTTGAGTTCTTTCACTATTCAAGATTCTATTATTTTGAATTTACAACGCGCCTGTGAAGCCTCTATTG
ATCTAGCTATGCACCTCATTGCTCAAGGAAAACTAGGTATCCCCCAAACTTCTCGTGATGCCTTTAAAATCCTTGAAGAA
AAACAAATGATAGATTCAAATTTAAGTAAAGAGCTTCAGGCAATGGTGGGGTTTAGAAATATTGCCGTACATGATTATCA
AGACTTACAGGGGCCGATTGTCTTAGCTATTCTCGATAAACATCTAAGTAGCTTCACCGACTTTATTCAAAAAATAAACT
CTCTAAGTTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31426.97 Da        Isoelectric Point: 8.0592

>AT222328 WP_006766123.1 NZ_CP085966:384762-385619 [Burkholderia dolosa]
MSAPLQRQAADDAKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYR
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLQELYALYPERTLNRMTSATPETVDALYEAIREDARRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFMKALGLK

Download         Length: 858 bp

>AT222328 NZ_CP117812:2338952-2339329 [Lentisphaera profundi]
ATGATTACAATTAATACAGAACATATTATAAAATCCCTTCAAGAACTCCACCCTGAAGGACTGATCTTATTTGGATCACA
TAGTAAAGGCTGTGCTCGTAAAGATAGTGATATTGACATCGCATTTTTGAGCTCAAAATCATTCAGTGAATACGATGTTT
TTTGCAAAGCTGAGGCATTAGCAAGTGAACTCAATTGTGACATCAACCTCATAAATCTTCAAAATGCTAGCACCGTCTTT
GCCTACAATATTTTGACAAGTGGAACTATCCTGCAGATAAGCAATGACTATCATTGGAACCGTTTTTCTTATCTAACTTA
TAGTCTCTATGCGAAACTCAATGAAGAACGACATGAAATTTTAACGGCCGTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References