Detailed information of TA system TA222326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 529022..529680
• Replicon: chromosome
• Accession: NZ_CP085964
• Organism: Campylobacter curvus strain FDAARGOS_1547

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LK426_RS02705
• Protein ID: WP_018137147.1
• Coordinates: 529022..529429 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7D3QZX2
• Locus tag: LK426_RS02710
• Protein ID: WP_018137148.1
• Coordinates: 529429..529680 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK426_RS02680 (LK426_02680)	524030..524875	+	846	WP_018137141.1	dimethyl sulfoxide reductase anchor subunit	-
LK426_RS02685 (LK426_02685)	524872..525522	+	651	WP_018137142.1	molecular chaperone TorD family protein	-
LK426_RS02690 (LK426_02690)	525660..526532	+	873	WP_169331156.1	4Fe-4S binding protein	-
LK426_RS02695 (LK426_02695)	526541..527314	+	774	WP_018137144.1	AraC family transcriptional regulator	-
LK426_RS02700 (LK426_02700)	527318..528571	+	1254	WP_018137145.1	radical SAM protein	-
LK426_RS02705 (LK426_02705)	529022..529429	-	408	WP_018137147.1	type II toxin-antitoxin system VapC family toxin	Toxin
LK426_RS02710 (LK426_02710)	529429..529680	-	252	WP_018137148.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LK426_RS02715 (LK426_02715)	530232..531647	+	1416	WP_018137150.1	hypothetical protein	-
LK426_RS02720 (LK426_02720)	531772..532263	-	492	WP_155827527.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• SpoVT-AbrB domain (8-56)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15457.80 Da
• Isoelectric Point: 5.7382

>T222326 WP_018137147.1 NZ_CP085964:c529429-529022 [Campylobacter curvus]
MFLLDTNICSYLISSTEPYSQNILSHLTKHGKKDIFISSITIAEMFYGIENSTQKELNLRLMSDFISNFGVLDFTSKCAA
SYGKIRLEMRNKNRRIGDMDMLIAAVALSNDLVLVTNNEKDFKDISELRMENWSI

Nucleotide

• Length: 408 bp

>T222326 NZ_CP117811:c2787669-2787418 [Lentisphaera profundi]
ATGAATGCAATGACATATACAGAAGCTAGACAAAATCTAGCTAAAACTATGGAGACTGTATGTAACAACCATGATCCAGT
AATCATCACTAGCAAAAGAGAAAGATCTGTTGTTATGATTTCTCTCGAAGATTACAGTGCAATGGAAGAAACAAGTTACT
TACTGCGTAGTCCTAAAAATGCTAAAAGACTACTTGAATCAATTTATGAAATTGAAAATGGCGGTGGTGTAGAACGAGAT
TTAATTGAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9540.01 Da
• Isoelectric Point: 9.8437

>AT222326 WP_018137148.1 NZ_CP085964:c529680-529429 [Campylobacter curvus]
MQVRLKVFKSGNSLALRLPKSLNLDNVKEFILKSFDNNEVILTPVKDDEWSGLFKTLNELKDAGVKFERAEPSLPQERNF
GFK

Nucleotide

• Length: 252 bp

>AT222326 NZ_CP117811:c2787421-2787167 [Lentisphaera profundi]
ATGAAAATAACATTCTCGACTAAAGCATGGGAAGATTATTTATATTGGCAAAAGCAAGATAAAAAAATCTTAAAACGAAT
CAATCTTTTGATCAAAGATATTGAACGAAACCCAAATGATGGATTAGGAAAGCCTGAGATTTTGAGAAATACACTATCTG
GTTACTGCTCTAGAAGAATTACAGATGAACACAGATTAGTTTATAAAATATTAGACAACAATTTAATTCTAATACAGGCT
AGGCATCATTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A7D3QZX2