Detailed information of TA system TA222323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/Fic-DUF4065
• Location: 421823..422853
• Replicon: chromosome
• Accession: NZ_CP085960
• Organism: Corynebacterium diphtheriae strain FDAARGOS_1552

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: LK405_RS02075
• Protein ID: WP_070794874.1
• Coordinates: 421823..422242 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A806GUF5
• Locus tag: LK405_RS02080
• Protein ID: WP_014318824.1
• Coordinates: 422287..422853 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK405_RS02060 (LK405_02060)	418480..419334	+	855	WP_014303121.1	hypothetical protein	-
LK405_RS02065 (LK405_02065)	419327..420235	-	909	WP_014309246.1	DUF1906 domain-containing protein	-
LK405_RS02070 (LK405_02070)	420364..421563	-	1200	WP_014318823.1	cation:proton antiporter	-
LK405_RS02075 (LK405_02075)	421823..422242	-	420	WP_070794874.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
LK405_RS02080 (LK405_02080)	422287..422853	-	567	WP_014318824.1	Panacea domain-containing protein	Antitoxin
LK405_RS02085 (LK405_02085)	423186..423461	+	276	WP_014309249.1	hypothetical protein	-
LK405_RS02095 (LK405_02095)	424133..424408	+	276	WP_014301596.1	hypothetical protein	-
LK405_RS02100 (LK405_02100)	424415..425167	+	753	WP_014318826.1	precorrin-6A synthase (deacetylating)	-
LK405_RS02105 (LK405_02105)	425186..425443	-	258	WP_010934589.1	mycoredoxin	-
LK405_RS02110 (LK405_02110)	425464..425967	-	504	WP_014303129.1	dihydrofolate reductase	-
LK405_RS02115 (LK405_02115)	425967..426779	-	813	WP_014318827.1	thymidylate synthase	-
LK405_RS02120 (LK405_02120)	426873..427633	-	761	Protein_414	3'(2'),5'-bisphosphate nucleotidase CysQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	421823..432486	10663

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (11-93)

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-116)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15477.61 Da
• Isoelectric Point: 8.2756

>T222323 WP_070794874.1 NZ_CP085960:c422242-421823 [Corynebacterium diphtheriae]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Nucleotide

• Length: 420 bp

>T222323 NZ_CP117811:1908609-1908869 [Lentisphaera profundi]
ATGAACTTTGAATATGATAAAAATAAAAGTCTGAGTAATAAACAAAAACACAACATTGATTTTGTCGAAGCCCAGCAACT
ATGGAACGATCCAGACAGATTAGAAATCCCAGGATTAACGAGTGATGAACCAAGGTATTTAATAATTGGTAAAATTGAAA
ATAAAATTTGGTCTGCCATCATAACTTATAGAAATAACAACATAAGAATTATTTCGGTTAGAAGATCTAGAGAAAAAGAG
GTTACATATTATGAAAGCTAA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 21053.55 Da
• Isoelectric Point: 4.5592

>AT222323 WP_014318824.1 NZ_CP085960:c422853-422287 [Corynebacterium diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI

Nucleotide

• Length: 567 bp

>AT222323 NZ_CP117811:1908859-1909080 [Lentisphaera profundi]
ATGAAAGCTAAACATTTTGACAAAATATTTGATGATGACAATGACGATATTTTAGCTCATGTAGATTTATCAAAAGCTAA
AAGACCTGATGAAGTTCAGAAGAGAGTTAATGTAGATTTTCCTATTTGGATGATTCAATCATTAGATAAAGAAGCGAGAA
GACTAGGTACTACAAGACAAGCAGTTATCAAATTTTGGATTGCTGACAAGTTATCCAGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A806GUF5