Detailed information of TA system TA222321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/Fic-DUF4065
• Location: 1317626..1318656
• Replicon: chromosome
• Accession: NZ_CP085959
• Organism: Corynebacterium diphtheriae strain FDAARGOS_1553

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: LK425_RS06265
• Protein ID: WP_227882238.1
• Coordinates: 1318237..1318656 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: Q6NIH9
• Locus tag: LK425_RS06260
• Protein ID: WP_010934564.1
• Coordinates: 1317626..1318192 (+)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK425_RS06220 (LK425_06220)	1312710..1313468	+	759	WP_010934592.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-
LK425_RS06225 (LK425_06225)	1313562..1314374	+	813	WP_014310197.1	thymidylate synthase	-
LK425_RS06230 (LK425_06230)	1314374..1314877	+	504	WP_014310196.1	dihydrofolate reductase	-
LK425_RS06235 (LK425_06235)	1314898..1315155	+	258	WP_014310195.1	mycoredoxin	-
LK425_RS06240 (LK425_06240)	1315174..1315926	-	753	WP_014310194.1	precorrin-6A synthase (deacetylating)	-
LK425_RS06245 (LK425_06245)	1315933..1316208	-	276	WP_014310193.1	hypothetical protein	-
LK425_RS06255 (LK425_06255)	1316880..1317155	-	276	WP_014309249.1	hypothetical protein	-
LK425_RS06260 (LK425_06260)	1317626..1318192	+	567	WP_010934564.1	Panacea domain-containing protein	Antitoxin
LK425_RS06265 (LK425_06265)	1318237..1318656	+	420	WP_227882238.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
LK425_RS06270 (LK425_06270)	1318914..1320113	+	1200	WP_014310192.1	cation:proton antiporter	-
LK425_RS06275 (LK425_06275)	1320242..1321150	+	909	WP_014310191.1	DUF1906 domain-containing protein	-
LK425_RS06280 (LK425_06280)	1321143..1321997	-	855	WP_014310190.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (10-93)

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-116)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15581.79 Da
• Isoelectric Point: 9.4634

>T222321 WP_227882238.1 NZ_CP085959:1318237-1318656 [Corynebacterium diphtheriae]
MVKKLVYLSRTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSVDVLLYPTIYDQAAVLLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Nucleotide

• Length: 420 bp

>T222321 NZ_CP117811:31134-31391 [Lentisphaera profundi]
ATGCAGACGATTACCTACACAAAAGCAAGAAACAACCTCGCTAAAGAAATGGAAAGAGTGAGTTCAGATCACGATTATAC
GGTGATAACCCGAGCTAATCAGGAGAGTGCAGTGCTGATGTCTTTGGAAGATTTTTCATCTTGGCAAGAAACGGCGTATT
TACTTTCGAGTCCAAGTAATGCAAAACGCTTGATGCGTTCACTTGAACAACTCGATAGTGGCGGAGGCCAAGTTAGGGAA
CTTATAGAGGATGATTAA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 21022.71 Da
• Isoelectric Point: 4.6246

>AT222321 WP_010934564.1 NZ_CP085959:1317626-1318192 [Corynebacterium diphtheriae]
MISILHVAARVLELRPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASGLRADDDRLVTQIWSGD
SSQLIDYERSVVDTVVSFYGDLESFHLSDLSHGFAWSTVRGNLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDALEQAADDVAAENAETLRLLAFI

Nucleotide

• Length: 567 bp

>AT222321 NZ_CP117811:31384-31650 [Lentisphaera profundi]
ATGATTAAAAAATTCTCTGACGATGCCTGGGACGATTATGTTTATTGGCAGACTCAAGATAAAAAGACACTCAAGCGAAT
AAACCTTTTGATCAAAGATACTGAGCGAGATCCATTTTCAGGGATCGGTAAACCAGAGCCACTTAAACATAATCTGAGTG
GTTCTTGGTCACGTAGAATAGATGAAAAAAACCGCATGGTTTACCGGATTAAAAAAGAAGGCGATCAAGAAATTTTAGAG
ATAGCGGCTTTGCGTTATCACTATTAA

Structures

Antitoxin

• AlphaFold DB: A0A2T1BUC0