Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 1079605..1080635 | Replicon | chromosome |
| Accession | NZ_CP085958 | ||
| Organism | Corynebacterium diphtheriae subsp. diphtheriae strain FDAARGOS_1554 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | LK418_RS05225 | Protein ID | WP_070794874.1 |
| Coordinates | 1080216..1080635 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A806GUF5 |
| Locus tag | LK418_RS05220 | Protein ID | WP_014318824.1 |
| Coordinates | 1079605..1080171 (+) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK418_RS05180 (LK418_05180) | 1074827..1075585 | + | 759 | WP_014318828.1 | 3'(2'),5'-bisphosphate nucleotidase CysQ | - |
| LK418_RS05185 (LK418_05185) | 1075679..1076491 | + | 813 | WP_014318827.1 | thymidylate synthase | - |
| LK418_RS05190 (LK418_05190) | 1076491..1076994 | + | 504 | WP_014303129.1 | dihydrofolate reductase | - |
| LK418_RS05195 (LK418_05195) | 1077015..1077272 | + | 258 | WP_010934589.1 | mycoredoxin | - |
| LK418_RS05200 (LK418_05200) | 1077291..1078043 | - | 753 | WP_014318826.1 | precorrin-6A synthase (deacetylating) | - |
| LK418_RS05205 (LK418_05205) | 1078050..1078325 | - | 276 | WP_014301596.1 | hypothetical protein | - |
| LK418_RS05215 (LK418_05215) | 1078997..1079272 | - | 276 | WP_014309249.1 | hypothetical protein | - |
| LK418_RS05220 (LK418_05220) | 1079605..1080171 | + | 567 | WP_014318824.1 | Panacea domain-containing protein | Antitoxin |
| LK418_RS05225 (LK418_05225) | 1080216..1080635 | + | 420 | WP_070794874.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LK418_RS05230 (LK418_05230) | 1080895..1082094 | + | 1200 | WP_014318823.1 | cation:proton antiporter | - |
| LK418_RS05235 (LK418_05235) | 1082223..1083131 | + | 909 | WP_014309246.1 | DUF1906 domain-containing protein | - |
| LK418_RS05240 (LK418_05240) | 1083124..1083978 | - | 855 | WP_014303121.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15477.61 Da Isoelectric Point: 8.2756
>T222319 WP_070794874.1 NZ_CP085958:1080216-1080635 [Corynebacterium diphtheriae subsp. diphtheriae]
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
MVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 420 bp
>T222319 NZ_CP117798:3447786-3448259 [Proteus mirabilis]
ATGGATTTCCCTACAGATTTGAATGGATGGACAATCTACGCACATCCTTGCTTTAAACAACAATATGATGAATTACTACA
AAAAGTCGAAGCTCTGAAAAAAAAATATCCCGAAGATTATCAGAAAAAAGCAGATACAAAAATTTTTGCTCATGTATTGA
AATCTATAGTAAACATCACAAATGACCCACGGGCACCAGAGTTTAGGTTGGGTAATACTTTAGGAGAAGAAAATAAAAAT
TGGTCACGAATTAAATTAGTAAATGGAAGATATCGTTTATTTTTTAGATTCAGTTTTAAGGAAAAGATCATCATTCTGGC
ATGGATAAATGATAATGATACTTTGCGAACTTATGGCAATAAAACTGATGCTTACCGAGTCTTTGAGAAAAAACTAAAGA
AAGGTCATCCACCTAAAAATTGGAATGATTTATTTAGTGACTGTATAAATGAAGCTGACTGTCAGGATCCTTAA
ATGGATTTCCCTACAGATTTGAATGGATGGACAATCTACGCACATCCTTGCTTTAAACAACAATATGATGAATTACTACA
AAAAGTCGAAGCTCTGAAAAAAAAATATCCCGAAGATTATCAGAAAAAAGCAGATACAAAAATTTTTGCTCATGTATTGA
AATCTATAGTAAACATCACAAATGACCCACGGGCACCAGAGTTTAGGTTGGGTAATACTTTAGGAGAAGAAAATAAAAAT
TGGTCACGAATTAAATTAGTAAATGGAAGATATCGTTTATTTTTTAGATTCAGTTTTAAGGAAAAGATCATCATTCTGGC
ATGGATAAATGATAATGATACTTTGCGAACTTATGGCAATAAAACTGATGCTTACCGAGTCTTTGAGAAAAAACTAAAGA
AAGGTCATCCACCTAAAAATTGGAATGATTTATTTAGTGACTGTATAAATGAAGCTGACTGTCAGGATCCTTAA
Antitoxin
Download Length: 189 a.a. Molecular weight: 21053.55 Da Isoelectric Point: 4.5592
>AT222319 WP_014318824.1 NZ_CP085958:1079605-1080171 [Corynebacterium diphtheriae subsp. diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
>AT222319 NZ_CP117798:3447444-3447779 [Proteus mirabilis]
ATGCTAACCCACGTTTGCACTGACAACATCGCTCTTGAAGCTGATTCAAAAATAACAGAACGTCATCAAACCACAATTCC
CGCGTCAATTAGAGAAGCTCTACATCTTAGTGGTGGAGATCGTATTCACTACAAATTACTGAGCACTGGTGATGTACTTA
TCTCACGTCACAGCGATGGATCTGAAGATCCTGTTATGGCATCGTTTCTTAATTTTCTCGCTCAAGATATAACTAATCAT
CCTCAAACCATTCAACCTCTCGATATATCTCGTGGTTTTGAATTAGTTGAAGGTATGGATATCAACCTTGACGATGACAT
CACCGATAACGAATAA
ATGCTAACCCACGTTTGCACTGACAACATCGCTCTTGAAGCTGATTCAAAAATAACAGAACGTCATCAAACCACAATTCC
CGCGTCAATTAGAGAAGCTCTACATCTTAGTGGTGGAGATCGTATTCACTACAAATTACTGAGCACTGGTGATGTACTTA
TCTCACGTCACAGCGATGGATCTGAAGATCCTGTTATGGCATCGTTTCTTAATTTTCTCGCTCAAGATATAACTAATCAT
CCTCAAACCATTCAACCTCTCGATATATCTCGTGGTTTTGAATTAGTTGAAGGTATGGATATCAACCTTGACGATGACAT
CACCGATAACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|