Detailed information of TA system TA222318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 898525..899132
• Replicon: chromosome
• Accession: NZ_CP085957
• Organism: Finegoldia magna strain FDAARGOS_1556

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LK404_RS04595
• Protein ID: WP_227904478.1
• Coordinates: 898941..899132 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LK404_RS04590
• Protein ID: WP_094207779.1
• Coordinates: 898525..898902 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK404_RS04575 (LK404_04575)	893778..894491	+	714	WP_227904474.1	hypothetical protein	-
LK404_RS04580 (LK404_04580)	894534..897953	-	3420	WP_227904476.1	pyruvate carboxylase	-
LK404_RS04585 (LK404_04585)	897965..898384	-	420	WP_094206434.1	cytidine/deoxycytidylate deaminase family protein	-
LK404_RS04590 (LK404_04590)	898525..898902	-	378	WP_094207779.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LK404_RS04595 (LK404_04595)	898941..899132	-	192	WP_227904478.1	type II toxin-antitoxin system HicA family toxin	Toxin
LK404_RS04600 (LK404_04600)	899241..899498	+	258	WP_227904480.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LK404_RS04605 (LK404_04605)	899540..900850	-	1311	WP_227904482.1	glutathionylspermidine synthase	-
LK404_RS04610 (LK404_04610)	900843..902147	-	1305	WP_227904484.1	glutamate-cysteine ligase family protein	-
LK404_RS04615 (LK404_04615)	902150..902620	-	471	WP_227904485.1	Cys-tRNA(Pro) deacylase	-
LK404_RS04620 (LK404_04620)	902746..903504	+	759	WP_227904487.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	889971..899498	9527

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7072.34 Da
• Isoelectric Point: 10.7933

>T222318 WP_227904478.1 NZ_CP085957:c899132-898941 [Finegoldia magna]
MPLTGKELAKIAKQNGWREIRVTGSHHHFVKDGFSTIVTIPIHGNKDLKKGLEQKILKDLGLK

Nucleotide

• Length: 192 bp

>T222318 NZ_CP117798:3231943-3232512 [Proteus mirabilis]
ATGACAAACTATACTGTTTTGCTTGATGCCTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTTGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGGCAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAATACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGGATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCTCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14275.26 Da
• Isoelectric Point: 4.4377

>AT222318 WP_094207779.1 NZ_CP085957:c898902-898525 [Finegoldia magna]
MLKSYPAIFHKEEDSYWVEFPEFGGGTEGDNIEEAMVNAHQMLESVLATFIDEDIPLPKPSDITKIKVEDGFTSMIQVDP
TPFIKNNKTIRKNVTVPEWLVRLCDRQNINYSEVLTTALEKKINA

Nucleotide

• Length: 378 bp

>AT222318 NZ_CP117798:3231491-3231943 [Proteus mirabilis]
ATGAATACGATAAGTGAGAGACTTAGTGCTGAAGATATTGCATTAGCAAAATTAAGTAGCCAAGAGCTATCCGCTGTTAT
GGATATTAATGGCAAAACGCAGAAGCTATCCATTATAGATAAGACGGGTAATAATCATATTGTACAAATACCAAATAGTG
CATTACGCCTAATGATTGAAATTCTTACTCAACTAGGGCAAGGGAATACTGTTAGTATCACACCAATCCATGCTGAGCTA
ACGACACAGGAAGCGGCTGATATACTCAATATGTCCCGTCCTACATTTGTAAAATTATTAGATACACGAGCGATACCCTA
CTCTAGAAAAGGAAATCGTAGGAAAGTTGCTTATGCTGATATTGTTGCTTATAAAAATGAATTGGAGCAAAAACGACTTG
ATGCCCTTGCTGAATTATCGCAATTAGATCAAGAAATGGATATGGGGTATTAA