Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
| Location | 790815..791362 | Replicon | chromosome |
| Accession | NZ_CP085957 | ||
| Organism | Finegoldia magna strain FDAARGOS_1556 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D6S9C3 |
| Locus tag | LK404_RS04040 | Protein ID | WP_002835876.1 |
| Coordinates | 790815..791093 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LK404_RS04045 | Protein ID | WP_227906090.1 |
| Coordinates | 791090..791362 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK404_RS04010 (LK404_04010) | 785956..786552 | + | 597 | WP_227906086.1 | sulfur carrier protein ThiS adenylyltransferase ThiF | - |
| LK404_RS04015 (LK404_04015) | 786542..787306 | + | 765 | WP_094207918.1 | thiazole synthase | - |
| LK404_RS04020 (LK404_04020) | 787314..788468 | + | 1155 | WP_227906087.1 | 2-iminoacetate synthase ThiH | - |
| LK404_RS04025 (LK404_04025) | 788598..789629 | - | 1032 | WP_227906088.1 | PDDEXK nuclease domain-containing protein | - |
| LK404_RS04030 (LK404_04030) | 789812..790387 | + | 576 | WP_094206621.1 | ECF transporter S component | - |
| LK404_RS04035 (LK404_04035) | 790493..790750 | + | 258 | WP_227906089.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| LK404_RS04040 (LK404_04040) | 790815..791093 | - | 279 | WP_002835876.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| LK404_RS04045 (LK404_04045) | 791090..791362 | - | 273 | WP_227906090.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LK404_RS04050 (LK404_04050) | 791444..791755 | - | 312 | WP_227906091.1 | hypothetical protein | - |
| LK404_RS04055 (LK404_04055) | 791802..793613 | - | 1812 | WP_227906092.1 | heavy metal translocating P-type ATPase | - |
| LK404_RS04060 (LK404_04060) | 793613..793828 | - | 216 | WP_227906093.1 | cation transporter | - |
| LK404_RS04065 (LK404_04065) | 793868..794269 | - | 402 | WP_227906094.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| LK404_RS04070 (LK404_04070) | 794399..794632 | + | 234 | WP_094205022.1 | DUF6290 family protein | - |
| LK404_RS04075 (LK404_04075) | 794632..794898 | + | 267 | WP_227906095.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LK404_RS04080 (LK404_04080) | 794910..795638 | - | 729 | WP_227906096.1 | biotin--[acetyl-CoA-carboxylase] ligase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 11010.80 Da Isoelectric Point: 9.3997
>T222317 WP_002835876.1 NZ_CP085957:c791093-790815 [Finegoldia magna]
MKYEIKFTSKFKKDVKIAKKQNKNIEKLFEVIELLADGQTLDTKYRDHSLIGNYKNTRECHIEPDWILIYEIRNDILVLI
LNRVGSHSELFR
MKYEIKFTSKFKKDVKIAKKQNKNIEKLFEVIELLADGQTLDTKYRDHSLIGNYKNTRECHIEPDWILIYEIRNDILVLI
LNRVGSHSELFR
Download Length: 279 bp
>T222317 NZ_CP117798:2391973-2392464 [Proteus mirabilis]
ATGGGAAAAGTAACAGCACCTGAGCCGTTATCAAACTCACATGAAGTGGCTGATTTTTATAGTAGTGAAAATGTATTAGA
TAACTGGATAAAACAAAGAGGTTTAAAAAACCAATTTTTAGGTGCATCCCGTACATTTGTGGTCTGTGAAAAAAATAAAA
AACGTGTTGTTGGGTACTATTCTTTAGCAACAGGTAGTGTTAACCATACTGAAGCAATGAGTCATATTCGTCGCAATATG
CCAGACCCAATACCCGTGATCATTTTAGCTAGACTTGCTGTTGATAAAACTTTTCATGGAAAAGGTCTTGGTGCCGATTT
GTTAAGAGATGCAGTTTTGCGTTGTCATCATGTAGCTGAAAACATTGGTGTTAGAGCGATTATGGTTCATGCTTTAACTG
AAAACGCAAAACATTTCTACCTTCATCATGGTTTCAAAGCTTCTTCGACTCAAGACAAAATCTTATTCTTAGCACTAAAA
AAGAAAATATAG
ATGGGAAAAGTAACAGCACCTGAGCCGTTATCAAACTCACATGAAGTGGCTGATTTTTATAGTAGTGAAAATGTATTAGA
TAACTGGATAAAACAAAGAGGTTTAAAAAACCAATTTTTAGGTGCATCCCGTACATTTGTGGTCTGTGAAAAAAATAAAA
AACGTGTTGTTGGGTACTATTCTTTAGCAACAGGTAGTGTTAACCATACTGAAGCAATGAGTCATATTCGTCGCAATATG
CCAGACCCAATACCCGTGATCATTTTAGCTAGACTTGCTGTTGATAAAACTTTTCATGGAAAAGGTCTTGGTGCCGATTT
GTTAAGAGATGCAGTTTTGCGTTGTCATCATGTAGCTGAAAACATTGGTGTTAGAGCGATTATGGTTCATGCTTTAACTG
AAAACGCAAAACATTTCTACCTTCATCATGGTTTCAAAGCTTCTTCGACTCAAGACAAAATCTTATTCTTAGCACTAAAA
AAGAAAATATAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 10231.71 Da Isoelectric Point: 4.3912
>AT222317 WP_227906090.1 NZ_CP085957:c791362-791090 [Finegoldia magna]
MSTVNLNIRTDKEIKEKAENIFEELGLNMTTAINMFLRTSIRENGIPFDLKIDSVNDETKLAIEEGKKIADDKTIEGYVS
IEELKKALEI
MSTVNLNIRTDKEIKEKAENIFEELGLNMTTAINMFLRTSIRENGIPFDLKIDSVNDETKLAIEEGKKIADDKTIEGYVS
IEELKKALEI
Download Length: 273 bp
>AT222317 NZ_CP117798:2391719-2391985 [Proteus mirabilis]
ATGAAAGCTGATGTACAACTCAATATTCGCGCTAAAGAATCACAACGCGCACTTATTGATACTGCTGCTGAAATTCTCCA
TAAATCTCGTACTGACTTTATTCTTGAGACAGCATGCCAAGCTGCTGAAGACGTCATTTTAGACCGTAGAACCTTTAATT
TAAATGATGCTCAATATGCGGAATTTATAGAAATTATTGATGCGCCGGTTGATATTGACCCTGCTCTTGAAAAGTTATTA
ATGAGAAAACCATTATGGGAAAAGTAA
ATGAAAGCTGATGTACAACTCAATATTCGCGCTAAAGAATCACAACGCGCACTTATTGATACTGCTGCTGAAATTCTCCA
TAAATCTCGTACTGACTTTATTCTTGAGACAGCATGCCAAGCTGCTGAAGACGTCATTTTAGACCGTAGAACCTTTAATT
TAAATGATGCTCAATATGCGGAATTTATAGAAATTATTGATGCGCCGGTTGATATTGACCCTGCTCTTGAAAAGTTATTA
ATGAGAAAACCATTATGGGAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|