Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1896668..1897319 Replicon chromosome
Accession NZ_CP085954
Organism Tsukamurella paurometabola strain FDAARGOS_1558

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LK411_RS09500 Protein ID WP_164711501.1
Coordinates 1896891..1897319 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LK411_RS09495 Protein ID WP_126194987.1
Coordinates 1896668..1896898 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK411_RS09470 (LK411_09470) 1892109..1893212 + 1104 WP_126194982.1 citrate synthase 2 -
LK411_RS09475 (LK411_09475) 1893216..1894340 + 1125 WP_126194983.1 phosphoserine transaminase -
LK411_RS09480 (LK411_09480) 1894366..1895151 + 786 WP_126194984.1 septation protein SepH -
LK411_RS09485 (LK411_09485) 1895156..1895908 + 753 WP_126194985.1 hypothetical protein -
LK411_RS09490 (LK411_09490) 1895924..1896577 + 654 WP_126194986.1 hypothetical protein -
LK411_RS09495 (LK411_09495) 1896668..1896898 + 231 WP_126194987.1 hypothetical protein Antitoxin
LK411_RS09500 (LK411_09500) 1896891..1897319 + 429 WP_164711501.1 PIN domain-containing protein Toxin
LK411_RS09505 (LK411_09505) 1897628..1898911 - 1284 WP_126194989.1 MFS transporter -
LK411_RS09510 (LK411_09510) 1898948..1899226 - 279 WP_126194990.1 DUF2537 domain-containing protein -
LK411_RS09515 (LK411_09515) 1899223..1900023 - 801 WP_126194991.1 RNA methyltransferase -
LK411_RS09520 (LK411_09520) 1900054..1901205 + 1152 WP_126194992.1 GNAT family N-acetyltransferase -
LK411_RS09525 (LK411_09525) 1901305..1901760 - 456 WP_126194993.1 MarR family transcriptional regulator -
LK411_RS09530 (LK411_09530) 1901862..1902071 + 210 WP_126194994.1 DUF2530 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(6-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15215.55 Da        Isoelectric Point: 6.4869

>T222314 WP_164711501.1 NZ_CP085954:1896891-1897319 [Tsukamurella paurometabola]
MSDVELPDVNVLVALLSANHVHHTTARDWFASTPRFATTPITEAGLVRMALNRAVMGTAITAQQALASLASLRADDRAEF
VPDESSLAAPSIDLVGLAGHKQVTDLHLVNLMARHSGVLVTLDTRIRPVLTPADQPLVRVLL

Download         Length: 429 bp

>T222314 NZ_CP117797:65929-66189 [Fusobacterium nucleatum]
ATGAATAATTTAGTATGGACACATAAAGCTTGGCAAGATTACCTATATTGGCAAACTCAGGATAAAAAAACTTTAAAAAA
GATAAATAAATTAGTCAAAGGTATTGAAAGAAATGGAGCTTTAAATGGGATAGGCAAACCAGAAGTATTAAAAAATGAAA
ATGCATATAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTGTAGACGGGTTTATATGGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 7977.02 Da        Isoelectric Point: 4.6816

>AT222314 WP_126194987.1 NZ_CP085954:1896668-1896898 [Tsukamurella paurometabola]
VRTTLDISPRVLAAARARVNAGQNKSIGEAVSELAALGLETATASRRPTDHGLVMLPSAPDHVITSEMVEDALLDE

Download         Length: 231 bp

>AT222314 NZ_CP117797:65682-65936 [Fusobacterium nucleatum]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTGGATAATGATGAAGATAT
AATTATAACAAGAAAAAATGAAAGAAATGTTGTTCTATTAAGTCTTGATAAATACAATGAGTTTTTAAAAGCTATGAGAA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAGGCAGGAAAAGGAGAAATCCATGATTTAATAGAG
GCTGATGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References