Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1638584..1639082 Replicon chromosome
Accession NZ_CP085953
Organism Granulicatella elegans strain FDAARGOS_1559

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LK443_RS08130 Protein ID WP_227931419.1
Coordinates 1638584..1638838 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LK443_RS08135 Protein ID WP_227931420.1
Coordinates 1638840..1639082 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK443_RS08115 (LK443_08115) 1636468..1637172 - 705 WP_227931418.1 ribonuclease III -
LK443_RS08120 (LK443_08120) 1637656..1637850 + 195 Protein_1545 transposase -
LK443_RS08125 (LK443_08125) 1637951..1638535 - 585 Protein_1546 ion channel -
LK443_RS08130 (LK443_08130) 1638584..1638838 - 255 WP_227931419.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LK443_RS08135 (LK443_08135) 1638840..1639082 - 243 WP_227931420.1 DUF6290 family protein Antitoxin
LK443_RS08140 (LK443_08140) 1639483..1639692 - 210 WP_227931421.1 hypothetical protein -
LK443_RS08145 (LK443_08145) 1639869..1641083 - 1215 WP_227931422.1 GTPase HflX -
LK443_RS08150 (LK443_08150) 1641084..1642028 - 945 WP_227931423.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
LK443_RS08155 (LK443_08155) 1642030..1642755 - 726 WP_227931424.1 glycerophosphodiester phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10095.84 Da        Isoelectric Point: 11.1074

>T222313 WP_227931419.1 NZ_CP085953:c1638838-1638584 [Granulicatella elegans]
MYKLVPTRRFIKQLKKLDRFTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQILDNELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T222313 NZ_CP117782:3677290-3677622 [Burkholderia sp. FERM BP-3421]
ATGGCATTCGATTGGACGATCGTTTACTACAACGAACGCGTGAAGCGCGATGTGCTTGCGTTCCCGGTCGGGATTCTGGC
GGACTACCTCAGGCTGTTGGACCTGATGCAGGAGTTCGGCGCAGATCTGCGCATGCCGTACTCCCGCGCCATGGGTAACG
GGTTGTTTGAACTGCGTCCAAAGGGTAGGGAAGGCATCGGGCGAGTGTTCTATTGCACGCATGTGGGGCGGCAAGTCGTC
GTGCTGCACGCCTTCGTCAAGAAGACTCAGGAAACGCCGCCGCATGAGTTGCGGATAGCGCAAATACGTTTGAGAGAGGT
TCGTCATGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9134.33 Da        Isoelectric Point: 3.9682

>AT222313 WP_227931420.1 NZ_CP085953:c1639082-1638840 [Granulicatella elegans]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLDDLGKGVEPITWEEMMHDLGLEEE

Download         Length: 243 bp

>AT222313 NZ_CP117782:3677615-3677950 [Burkholderia sp. FERM BP-3421]
ATGGCTGAGGAAAAAGCAGGAAAGCGTGTCCGCGCGGCGGGATTCAATCCGGTTCCGCATACGGCGGACGATACGGCACG
TCTGCTTGCCGCCGGCGGGGTCAAGGAGGCGTACGACGCGCTGGAGGATGAATACACCGCGTTGCGCGCCATCCTGTCCG
CGCGCCGGGATGCCGGGCTGACCCAGGCCCAGATCGCGGAGCGGATGGGAACGACGGCGTCGGCGGTGTCGCGCCTCGAG
GCGTCTCTCGCCAGCGAAAAACATTCGCCGTCGTTCGCGACGCTCAGAAAATACGCCGCGGCTTGCGGCAAGCGTCTGGT
GATTTCATTTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References