Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1553470..1554017 Replicon chromosome
Accession NZ_CP085953
Organism Granulicatella elegans strain FDAARGOS_1559

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LK443_RS07700 Protein ID WP_227931347.1
Coordinates 1553745..1554017 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LK443_RS07695 Protein ID WP_227931346.1
Coordinates 1553470..1553745 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK443_RS07675 (LK443_07675) 1549915..1550364 - 450 WP_227931343.1 PTS sugar transporter subunit IIA -
LK443_RS07680 (LK443_07680) 1550463..1551527 - 1065 WP_227932475.1 L-ascorbate 6-phosphate lactonase -
LK443_RS07685 (LK443_07685) 1551549..1552187 - 639 WP_227931344.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
LK443_RS07690 (LK443_07690) 1552523..1553152 + 630 WP_227931345.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
LK443_RS07695 (LK443_07695) 1553470..1553745 + 276 WP_227931346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LK443_RS07700 (LK443_07700) 1553745..1554017 + 273 WP_227931347.1 type II toxin-antitoxin system YafQ family toxin Toxin
LK443_RS07705 (LK443_07705) 1554091..1554324 - 234 WP_006702633.1 YneF family protein -
LK443_RS07710 (LK443_07710) 1554431..1555405 - 975 WP_227931348.1 LD-carboxypeptidase -
LK443_RS07715 (LK443_07715) 1555422..1555904 - 483 WP_227931349.1 prolyl-tRNA synthetase associated domain-containing protein -
LK443_RS07720 (LK443_07720) 1556032..1557129 + 1098 WP_227931350.1 ferrochelatase -
LK443_RS07725 (LK443_07725) 1557250..1558569 + 1320 WP_227931351.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-67)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10808.57 Da        Isoelectric Point: 8.0038

>T222312 WP_227931347.1 NZ_CP085953:1553745-1554017 [Granulicatella elegans]
MYKLKFTNKFKKSYKLMKKRGYDISLLEEVVYQLSQGIPLEPKYRNHMLTGDYTGYYECHIKPDWLLIYLKEEDIITLTL
IDTGSHSDFF

Download         Length: 273 bp

>T222312 NZ_CP117782:c2495670-2495497 [Burkholderia sp. FERM BP-3421]
GTGAAATTCAGCGAATTCAGGCGATGGTTGGTCGATCGGGGCGCCACCTTCGAGGAGGGGGCGAAGCATGCGAAGGTGTA
CCTGAATGGCCGGCAGACGACGCTTCCGAGGCACTCCGGAGAGATAGGGGAGGGCTTGAGGAGGGCAATTTGCAAGCAAC
TGGGATTGGCGTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10223.68 Da        Isoelectric Point: 4.4501

>AT222312 WP_227931346.1 NZ_CP085953:1553470-1553745 [Granulicatella elegans]
MATSPTQIRIDTTIKEDANVLFSRLGLDMSSAVNIFLRQCLLRGGLPFTIELPKYNEETLAAMEDAKRISRDPSIQGYSS
INELFKALEEE

Download         Length: 276 bp

>AT222312 NZ_CP117782:c2495398-2494976 [Burkholderia sp. FERM BP-3421]
ATGTTGCGTTATCCGGCCAAACTGGAGCGGGACGGAGAGGGATACGTCGTAACGTTTCGAGATATTCCTGAAGCCATTAC
CTCCGGCGCCACGAAGGAGGAGGCGTGGGTCATGGCGGAGGACGCGCTGCTGACCGCGATGGACTTCTACATCGAAGATG
AGCGGGTGGTTCCCCCTCCCTCCGGCGCAAGACGTGGCGAGGCGTTCGTGGAGTTGCCCGCGAGCGTGTCCGCCAAGGTT
CTGCTTCTGAATGCGATGGTGGATCAAAGCGTGCGGCCGTTCGAACTGGCCAAGCGGATGGGGATCCGGCCTCAGGAGGT
TCAAAGGATCATGGATCTGTCGCACGTGACGAAGATCGACACGCTGGAGGCGGCGTTTGCTGCGCTCGGAAAGCGTCTGG
AGATTACCGCCGAGGCGTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References