Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1319359..1319948 Replicon chromosome
Accession NZ_CP085952
Organism Haemophilus influenzae strain FDAARGOS_1560

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag LK401_RS06685 Protein ID WP_005653200.1
Coordinates 1319359..1319607 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag LK401_RS06690 Protein ID WP_005653201.1
Coordinates 1319604..1319948 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK401_RS06660 (LK401_06660) 1314839..1315471 + 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -
LK401_RS06665 (LK401_06665) 1315473..1316099 + 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
LK401_RS06670 (LK401_06670) 1316206..1317396 - 1191 WP_005657030.1 amino acid aminotransferase -
LK401_RS06675 (LK401_06675) 1317536..1318624 - 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
LK401_RS06680 (LK401_06680) 1318694..1319188 - 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
LK401_RS06685 (LK401_06685) 1319359..1319607 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
LK401_RS06690 (LK401_06690) 1319604..1319948 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LK401_RS06695 (LK401_06695) 1319992..1322601 + 2610 WP_011272463.1 aminopeptidase N -
LK401_RS06700 (LK401_06700) 1322673..1323287 - 615 WP_005657019.1 riboflavin synthase -
LK401_RS06705 (LK401_06705) 1323331..1324725 + 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T222310 WP_005653200.1 NZ_CP085952:1319359-1319607 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T222310 NZ_CP117781:1502470-1503363 [Burkholderia sp. FERM BP-3421]
ATGAGCATGATCGATACGGAACCCGCCGGGCGCGACGCCGTCGCCTCGTTCCACGCGCGGCTCGCCTGCTGCCCGGAGCG
GCGCGTGCAGGCCGGCGCGGCCGGCGTGATCGGCTATCGCGAGGCGGGCGCGGCCGCGGGCGGCCTGCCGGTGGTGCTGT
TGCACGGCATCGGGTCGGGCGCGGCGTCGTGGGTTCGGCAGCTCGACGCGCTGGGCGCGGCGCGGCGCACGCTGGCCTGG
GATGCGCCCGGCTATCTCGCGTCGACGCCGGTGAGCGCCGCATCGCCGCTCGCCGCCGATTACGCGGCGGCGCTCGCGGC
CTGGCTCGATGCGCTCGGGATCGGACGCTGCGTCCTGGTCGGTCATTCGCTCGGCGCGCTGGTCGCGGGCGGCTTCGCCC
GCGCATGGCCCGGGCGGCTCGCCGGCCTGCTGCTGCTGTCGCCGGCGGGCGGCTATGGCGCCGCGCCGGCCGAGTTGCGC
GTCGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCGCGCAGGGGCTGGCGGCGCGGCGCAGCGCGGCGAT
GCTGTCCGCGCACGCGGAGCCGGCCGCGCAGGACTGGGTGCGCTGGAACATGGCGCGCATCGCGCCCGGCGGTTATGCGC
AGGCGACGCATCTGCTCGCGAACGCGGATCTGGTCGCGGATCTCGGCGGTTTCGGCGGCCGCGTGGCGGTTGCCGTCGGC
GCGCTCGACACGATCACGCCGCCCGCCGCCTGCGAGCGCATCGCGGCGGCCGCGCGGGTCGGATTGCAGGTGATTCCCCA
GGTCGGGCATGCGGGCTATGTCGAGGCGCCCAATGTCTACAGCGCGCTGATCGACGCATTCTGCCGCCAGTGTGAAGGCT
CGGAGGCCGCATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT222310 WP_005653201.1 NZ_CP085952:1319604-1319948 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT222310 NZ_CP117781:1503360-1504196 [Burkholderia sp. FERM BP-3421]
ATGAACGAACCCCGCGACGCCGCCGAGGCGAACTACATCGTGCCGGGGCTGGAACGTGGGCTGCGGTTGCTCGCGGAGTT
CACGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCACGACCGTATTCCGCCTGC
TGCAGACGCTCGAATCGATGGGCTTTCTCGAACGCGTGGACCGGGACCGCAACTATCGGCTCGGCGTCGCGGTGCTGCGG
CTCGGCTTCGAATACCTGAGTTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGAGGGCCTGCGCGAGGCGACGGG
CTTCACGACCCATATCGTGATCCGCGACGGCCGTGACGTCGTGTTCGTCGCGAAGGCGCAAAGCCTCGCGTCCGCGTTCA
GCTCGGTGCGGGTCAATGCCGGCACGCGGCTGCCCGCGCACGCGACCACCCACGGCCATGTGCTGATGGGCGACCTGTCG
CTCGACGCGCTGCGCGCGCTGTATCCGGAGCCGCGCCTCGAACGCGCGACGCCCCACACGCCGACCACGGTCGACGCGTT
GTACGCGCTCGTGCGCGCCGACGCGGCGCGCGGCTACGGGCTCAGCCATTCATCGTTCGAACGCGGCATCTCGGTGATCA
CCGCGCCGGTGCGCAACGACACGGGAAAGATCGCCGCCTGCCTCGCGGTGACGGTCCCGCGCCCGGAGATCGACGCGACG
CTGCTCGCCGACGGGCTCGTCGACAAGGTGCTGCGCGCGGCCGCCGAGCTGTCGCGGCGGCTCAACTACCGCTCCGATGA
AGAGCATACCTATCTGAAGATCCTGGGGCTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References