Detailed information of TA system TA222308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 759583..760214
• Replicon: chromosome
• Accession: NZ_CP085952
• Organism: Haemophilus influenzae strain FDAARGOS_1560

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LK401_RS03935
• Protein ID: WP_058222150.1
• Coordinates: 759879..760214 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: LK401_RS03930
• Protein ID: WP_005692346.1
• Coordinates: 759583..759879 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK401_RS03915 (LK401_03915)	755349..756734	+	1386	WP_038440401.1	L-seryl-tRNA(Sec) selenium transferase	-
LK401_RS03920 (LK401_03920)	756731..758590	+	1860	WP_058222152.1	selenocysteine-specific translation elongation factor	-
LK401_RS03925 (LK401_03925)	758609..759463	+	855	WP_058222151.1	DUF3298 domain-containing protein	-
LK401_RS03930 (LK401_03930)	759583..759879	+	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LK401_RS03935 (LK401_03935)	759879..760214	+	336	WP_058222150.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LK401_RS03940 (LK401_03940)	760271..763528	-	3258	WP_265576986.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
LK401_RS03960 (LK401_03960)	763830..765128	+	1299	WP_006995277.1	trigger factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-107)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13148.92 Da
• Isoelectric Point: 4.9104

>T222308 WP_058222150.1 NZ_CP085952:759879-760214 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCYIQGNLVLIYQYV
IRDEFDEFDEFDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 336 bp

>T222308 NZ_CP117779:141285-141575 [Burkholderia sp. FERM BP-3421]
GTGCCGCAAGTAATCTGGACACGCAATGCCGCACGCGCTGTACAGCGAATGCACCAGTTTCTCGCCATGAAGGATCCGAC
GGCCGCGCAGCGCGCGGTTAAGGCGATCCGGGCCGGCGTCGACGTTCTGATCGACCAACCGCGTCTGGGCCGCCCCGTCG
ATGATCTCGACGTCGAATTCCGCGAGTGGTTGATCGATTTCGGCGATAGCGGCTACGTGGTGCTGTACCGTGTCGATGAA
GCTGGGGTGGTTATTCTGACGGTTCGCCATCAGCGCGAAGCAGGGTATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT222308 WP_005692346.1 NZ_CP085952:759583-759879 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT222308 NZ_CP117779:141025-141297 [Burkholderia sp. FERM BP-3421]
ATGGCAACCTCTATCAAACTTGACACGGGCATGCAGGATCGCGTCCGGCATCTGGCCGAACAGCGCCGGCGCACGCCGCA
CTGGATCATGCGCGAAGCCATCGCGCAGTACGTCGAGCGCGAAGAAAAGCGCGAGTCGATCCGGCAAGAGGCCGTTGAAG
CCTGGCACGATTATCAGACCACCGGGCTGCACGTGCCGCATGCGGACATGGACCGTTACATGGCGGAGTTGGAAGCCGGA
CGCGACGCGGAGCTGCCTGGGTGCCGCAAGTAA

Structures

Antitoxin

• AlphaFold DB: Q4QMK8