222307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 510229..510707 Replicon chromosome
Accession NZ_CP085952
Organism Haemophilus influenzae strain FDAARGOS_1560

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag LK401_RS02685 Protein ID WP_011272058.1
Coordinates 510229..510507 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag LK401_RS02690 Protein ID WP_011272059.1
Coordinates 510516..510707 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK401_RS02665 (LK401_02665) 505420..507090 - 1671 WP_058222165.1 fructose-specific PTS transporter subunit EIIC -
LK401_RS02670 (LK401_02670) 507092..508033 - 942 WP_011272055.1 1-phosphofructokinase -
LK401_RS02675 (LK401_02675) 508035..509534 - 1500 WP_058222164.1 fused PTS fructose transporter subunit IIA/HPr protein -
LK401_RS02680 (LK401_02680) 509606..510136 - 531 WP_038440586.1 hypothetical protein -
LK401_RS02685 (LK401_02685) 510229..510507 - 279 WP_011272058.1 virulence-associated protein VapD Toxin
LK401_RS02690 (LK401_02690) 510516..510707 - 192 WP_011272059.1 DUF5397 family protein Antitoxin
LK401_RS02695 (LK401_02695) 510779..512077 - 1299 WP_005691371.1 hemolysin family protein -
LK401_RS02700 (LK401_02700) 512128..512652 - 525 WP_038440582.1 DUF1523 family protein -
LK401_RS02705 (LK401_02705) 512679..513461 - 783 WP_038440581.1 YchF/TatD family DNA exonuclease -
LK401_RS02710 (LK401_02710) 513514..514497 - 984 WP_038440579.1 DNA polymerase III subunit delta' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T222307 WP_011272058.1 NZ_CP085952:c510507-510229 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T222307 NZ_CP117768:3338770-3338964 [Nostoc sp. UHCC 0926]
ATTAGCAAAGTACGCGAAGTCATTAAACGACTAGAAGCTGATGGTTGGTATCTTGCTAGAACCAAAGGTAGTCATCGACA
GTTCAAACATTCAGATAAACCCAGTACTGTAACAGTGTCTGGTAAGCCAAATGTGGATGTGCCAATTGGTACTCTTAAAA
ATATCTGGAGACAAGCTCAATTGGAGGAAGACTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT222307 WP_011272059.1 NZ_CP085952:c510707-510516 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp

>AT222307 NZ_CP117768:3338964-3339176 [Nostoc sp. UHCC 0926]
ATGCGTTATACAGTTGTGATTGAAAAGGGAGAAACTAGCTACGGCGCTTATGTCCCTGATTTACCAGGTTGTATAGCTGT
GGGTGAAACTTTAGAAGAAGTCAAGCAGATGATTGCAGAAGCTATTGAATTTCATCTAGAAGGAATGCTAGAAGATGGTT
TACCTATTCCTAAACCTACAAGCATCGCTCATGAGGTTGAAGTTGTAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References