Detailed information of TA system TA222304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1144570..1145105
• Replicon: chromosome
• Accession: NZ_CP085951
• Organism: Haemophilus influenzae strain FDAARGOS_1561

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LK431_RS05685
• Protein ID: WP_050846954.1
• Coordinates: 1144842..1145105 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A112WVR2
• Locus tag: LK431_RS05680
• Protein ID: WP_021035051.1
• Coordinates: 1144570..1144845 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK431_RS05665 (LK431_05665)	1141807..1142325	+	519	WP_227894291.1	ESPR-type extended signal peptide-containing protein	-
LK431_RS05670 (LK431_05670)	1142621..1143595	-	975	WP_111695640.1	zinc transporter permease subunit ZevB	-
LK431_RS05675 (LK431_05675)	1143598..1144218	-	621	WP_111695639.1	zinc transporter binding subunit ZevA	-
LK431_RS05680 (LK431_05680)	1144570..1144845	+	276	WP_021035051.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LK431_RS05685 (LK431_05685)	1144842..1145105	+	264	WP_050846954.1	YafQ family addiction module toxin	Toxin
LK431_RS05690 (LK431_05690)	1145200..1146870	+	1671	WP_044364316.1	energy-dependent translational throttle protein EttA	-
LK431_RS05695 (LK431_05695)	1146932..1147273	+	342	WP_050846956.1	SirB2 family protein	-
LK431_RS05700 (LK431_05700)	1147278..1149248	+	1971	WP_111695638.1	GNAT family N-acetyltransferase	-
LK431_RS05705 (LK431_05705)	1149245..1149418	+	174	WP_021035056.1	DUF5363 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10298.03 Da
• Isoelectric Point: 7.3198

>T222304 WP_050846954.1 NZ_CP085951:1144842-1145105 [Haemophilus influenzae]
MISVSEEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLN
THPEIFG

Nucleotide

• Length: 264 bp

>T222304 NZ_CP117764:c2186453-2186064 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10297.90 Da
• Isoelectric Point: 5.6663

>AT222304 WP_021035051.1 NZ_CP085951:1144570-1144845 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHNGREYKTLEE
FHQAMLSEMKL

Nucleotide

• Length: 276 bp

>AT222304 NZ_CP117764:c2186717-2186460 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A112WVR2