222303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 631535..632013 Replicon chromosome
Accession NZ_CP085951
Organism Haemophilus influenzae strain FDAARGOS_1561

Toxin (Protein)


Gene name VapD Uniprot ID A0A112WLN3
Locus tag LK431_RS03170 Protein ID WP_021034684.1
Coordinates 631735..632013 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag LK431_RS03165 Protein ID WP_012055040.1
Coordinates 631535..631726 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK431_RS03140 (LK431_03140) 627137..627769 + 633 WP_172453993.1 dTMP kinase -
LK431_RS03145 (LK431_03145) 627766..628746 + 981 WP_021034681.1 DNA polymerase III subunit delta' -
LK431_RS03150 (LK431_03150) 628782..629564 + 783 WP_111695253.1 YchF/TatD family DNA exonuclease -
LK431_RS03155 (LK431_03155) 629591..630115 + 525 WP_005669286.1 DUF1523 family protein -
LK431_RS03160 (LK431_03160) 630166..631464 + 1299 WP_021034683.1 hemolysin family protein -
LK431_RS03165 (LK431_03165) 631535..631726 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
LK431_RS03170 (LK431_03170) 631735..632013 + 279 WP_021034684.1 virulence-associated protein VapD Toxin
LK431_RS03175 (LK431_03175) 632109..632639 + 531 WP_021034685.1 hypothetical protein -
LK431_RS03180 (LK431_03180) 632711..634210 + 1500 WP_021034686.1 fused PTS fructose transporter subunit IIA/HPr protein -
LK431_RS03185 (LK431_03185) 634212..635153 + 942 WP_021034687.1 1-phosphofructokinase -
LK431_RS03190 (LK431_03190) 635155..636825 + 1671 WP_111695252.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.01 Da        Isoelectric Point: 4.9670

>T222303 WP_021034684.1 NZ_CP085951:631735-632013 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNELKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

>T222303 NZ_CP117763:21837-22196 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT222303 WP_012055040.1 NZ_CP085951:631535-631726 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT222303 NZ_CP117763:22196-22495 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112WLN3

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References