Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 566852..567456 Replicon chromosome
Accession NZ_CP085951
Organism Haemophilus influenzae strain FDAARGOS_1561

Toxin (Protein)


Gene name relE Uniprot ID A0A2S9RBL9
Locus tag LK431_RS02865 Protein ID WP_050948779.1
Coordinates 566852..567160 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag LK431_RS02870 Protein ID WP_005692346.1
Coordinates 567160..567456 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK431_RS02855 (LK431_02855) 562031..563329 - 1299 WP_006995277.1 trigger factor -
LK431_RS02860 (LK431_02860) 563630..566794 + 3165 WP_111695274.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
LK431_RS02865 (LK431_02865) 566852..567160 - 309 WP_050948779.1 type II toxin-antitoxin system YafQ family toxin Toxin
LK431_RS02870 (LK431_02870) 567160..567456 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LK431_RS02875 (LK431_02875) 567576..568430 - 855 WP_050951468.1 DUF3298 domain-containing protein -
LK431_RS02880 (LK431_02880) 568449..570308 - 1860 WP_111695273.1 selenocysteine-specific translation elongation factor -
LK431_RS02885 (LK431_02885) 570305..571690 - 1386 WP_111695272.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11949.72 Da        Isoelectric Point: 7.8657

>T222302 WP_050948779.1 NZ_CP085951:c567160-566852 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T222302 NZ_CP117762:c3313540-3313151 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT222302 WP_005692346.1 NZ_CP085951:c567456-567160 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT222302 NZ_CP117762:c3313804-3313547 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9RBL9

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References