Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 141692..142329 | Replicon | chromosome |
Accession | NZ_CP085951 | ||
Organism | Haemophilus influenzae strain FDAARGOS_1561 |
Toxin (Protein)
Gene name | VapC1 | Uniprot ID | A0A121YHB9 |
Locus tag | LK431_RS00730 | Protein ID | WP_021035685.1 |
Coordinates | 141692..142096 (-) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | VapB1 | Uniprot ID | A0A0H3PN67 |
Locus tag | LK431_RS00735 | Protein ID | WP_005656316.1 |
Coordinates | 142093..142329 (-) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LK431_RS00710 (LK431_00710) | 138172..138756 | - | 585 | WP_021035682.1 | primosomal replication protein | - |
LK431_RS00715 (LK431_00715) | 138789..140141 | - | 1353 | WP_021035683.1 | Na+/H+ antiporter family protein | - |
LK431_RS00720 (LK431_00720) | 140455..141144 | - | 690 | WP_021035684.1 | ribonuclease T | - |
LK431_RS00725 (LK431_00725) | 141218..141625 | - | 408 | WP_005688980.1 | lactoylglutathione lyase | - |
LK431_RS00730 (LK431_00730) | 141692..142096 | - | 405 | WP_021035685.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LK431_RS00735 (LK431_00735) | 142093..142329 | - | 237 | WP_005656316.1 | antitoxin | Antitoxin |
LK431_RS00740 (LK431_00740) | 142422..143147 | - | 726 | WP_111695399.1 | carboxy-S-adenosyl-L-methionine synthase CmoA | - |
LK431_RS00745 (LK431_00745) | 143201..143719 | - | 519 | WP_005688985.1 | isoprenylcysteine carboxyl methyltransferase family protein | - |
LK431_RS00750 (LK431_00750) | 143938..145704 | + | 1767 | WP_111695398.1 | aspartate--tRNA ligase | - |
LK431_RS00755 (LK431_00755) | 145726..146202 | + | 477 | WP_021035689.1 | dihydroneopterin triphosphate diphosphatase | - |
LK431_RS00760 (LK431_00760) | 146362..147102 | + | 741 | WP_005662961.1 | YebC/PmpR family DNA-binding transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 15690.26 Da Isoelectric Point: 8.9777
>T222300 WP_021035685.1 NZ_CP085951:c142096-141692 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK
Download Length: 405 bp
>T222300 NZ_CP117759:463405-463794 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 9007.16 Da Isoelectric Point: 4.2342
>AT222300 WP_005656316.1 NZ_CP085951:c142329-142093 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL
Download Length: 237 bp
>AT222300 NZ_CP117759:463141-463398 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A121YHB9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3PN67 |