Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 141692..142329 Replicon chromosome
Accession NZ_CP085951
Organism Haemophilus influenzae strain FDAARGOS_1561

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A121YHB9
Locus tag LK431_RS00730 Protein ID WP_021035685.1
Coordinates 141692..142096 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag LK431_RS00735 Protein ID WP_005656316.1
Coordinates 142093..142329 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK431_RS00710 (LK431_00710) 138172..138756 - 585 WP_021035682.1 primosomal replication protein -
LK431_RS00715 (LK431_00715) 138789..140141 - 1353 WP_021035683.1 Na+/H+ antiporter family protein -
LK431_RS00720 (LK431_00720) 140455..141144 - 690 WP_021035684.1 ribonuclease T -
LK431_RS00725 (LK431_00725) 141218..141625 - 408 WP_005688980.1 lactoylglutathione lyase -
LK431_RS00730 (LK431_00730) 141692..142096 - 405 WP_021035685.1 type II toxin-antitoxin system VapC family toxin Toxin
LK431_RS00735 (LK431_00735) 142093..142329 - 237 WP_005656316.1 antitoxin Antitoxin
LK431_RS00740 (LK431_00740) 142422..143147 - 726 WP_111695399.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
LK431_RS00745 (LK431_00745) 143201..143719 - 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
LK431_RS00750 (LK431_00750) 143938..145704 + 1767 WP_111695398.1 aspartate--tRNA ligase -
LK431_RS00755 (LK431_00755) 145726..146202 + 477 WP_021035689.1 dihydroneopterin triphosphate diphosphatase -
LK431_RS00760 (LK431_00760) 146362..147102 + 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-124)

Antitoxin

(6-44)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 15690.26 Da        Isoelectric Point: 8.9777

>T222300 WP_021035685.1 NZ_CP085951:c142096-141692 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T222300 NZ_CP117759:463405-463794 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT222300 WP_005656316.1 NZ_CP085951:c142329-142093 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT222300 NZ_CP117759:463141-463398 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A121YHB9


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References